Non-Small Cell Lung Cancer: Prognostic Importance of Positive FDG PET Findings in the Mediastinum for Patients with N0-N1 Disease at Pathologic Analysis

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dc.authoridHigginson, Daniel/0000-0002-6686-7454
dc.authoridHigginson, Daniel/0000-0002-6686-7454
dc.authoridKhandani, Amir H/0000-0003-3629-5472
dc.authorwosidHigginson, Daniel/X-8619-2018
dc.authorwosidHigginson, Daniel/AAW-4021-2020
dc.contributor.authorXie, Liyi
dc.contributor.authorSaynak, Mert
dc.contributor.authorVeeramachaneni, Nirmal K.
dc.contributor.authorFried, David V.
dc.contributor.authorJagtap, Mandar R.
dc.contributor.authorChiu, Wing Keung
dc.contributor.authorHigginson, Daniel S.
dc.date.accessioned2024-06-12T11:19:38Z
dc.date.available2024-06-12T11:19:38Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To assess the prognostic implications of mediastinal positron emission tomographic (PET) findings in patients undergoing curative resection of non-small cell lung cancer (NSCLC) who have histologically negative mediastinal lymph nodes (LNs), with the hypothesis that positive findings at PET are prognostic even in patients with negative histologic findings in the LNs. Materials and Methods: Records of patients with a preoperative PET undergoing curative surgery, without adjuvant radiation, for pathologic T1-3N0-1 NSCLC at the University of North Carolina between 2000 and 2006 were reviewed as an institutional review board-approved HIPAA-compliant retrospective study. Ninety patients were evaluable (all histologically negative in mediastinum; 44 with both mediastinoscopy and surgery); 13 patients had positive mediastinal PET findings, and 77 had negative mediastinal PET findings. Local-regional and distant failure rates in patients with and those without mediastinal abnormalities at preoperative PET were compared by using logistic regression and log-rank tests. Results: Median follow-up was 54.3 months (range, 1-99 months). There were higher rates of local-regional (P = .001) and distant (P,.001) failure as well as death (P = .001) in patients with postive PET findings than in patients with negative findings. In multivariable analysis (adjusting for other prognostic factors), positive PET findings in the mediastinum remained prognostic for distant failure (P,.001, hazard ratio = 6.9) and were marginally prognostic for local-regional failure (P = .093, hazard ratio = 1.9). Conclusion: Positive findings at preoperative PET in the mediastinum appear to have prognostic implications despite the mediastinal LNs being histologically negative. The high rate of local-regional and distant failure suggests that postoperative radiation therapy and/or chemotherapy may be particularly helpful in patients with positive mediastinal findings at preoperative PET.en_US
dc.identifier.doi10.1148/radiol.11110199
dc.identifier.endpage234en_US
dc.identifier.issn0033-8419
dc.identifier.issue1en_US
dc.identifier.pmid21813742en_US
dc.identifier.scopus2-s2.0-80053054631en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://doi.org/10.1148/radiol.11110199
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25284
dc.identifier.volume261en_US
dc.identifier.wosWOS:000295039000025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRadiological Soc North Americaen_US
dc.relation.ispartofRadiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPositron-Emission-Tomographyen_US
dc.subjectLymph-Nodesen_US
dc.subjectComputed-Tomographyen_US
dc.subjectLocal Recurrenceen_US
dc.subjectMetastasesen_US
dc.subjectGuidelinesen_US
dc.subjectPatternsen_US
dc.titleNon-Small Cell Lung Cancer: Prognostic Importance of Positive FDG PET Findings in the Mediastinum for Patients with N0-N1 Disease at Pathologic Analysisen_US
dc.typeArticleen_US

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