Histopathological Evidence of Lymph Node Metastasis in Papillary Thyroid Carcinoma

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dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridSarikas, Nurtac/0000-0002-2170-0300
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidSarikas, Nurtac/ABG-1224-2021
dc.authorwosidguler, beril/GYV-3937-2022
dc.authorwosidOzyilmaz, Filiz/A-4865-2016
dc.contributor.authorCan, Nuray
dc.contributor.authorTastekin, Ebru
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorSezer, Yavuz Atakan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSut, Necdet
dc.contributor.authorSarikas, Nurtac
dc.date.accessioned2024-06-12T11:12:02Z
dc.date.available2024-06-12T11:12:02Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractProphylactic lymph node dissection is still controversial due to the potentially surgery-related morbidity in management of papillary thyroid carcinomas. So, some histopathological predictors for lymph node metastasis in thyroidectomy specimens may reveal importance. The objective of this study was to define histomorphological indicators of lymph node metastasis in the patients who had been performed thyroidectomy without lymph node dissection. Clinicopathological features of patients archived in Department of Pathology at Trakya University Medical Faculty were reviewed. A total of 211 patients who had been diagnosed as papillary carcinoma and had been performed total thyroidectomy/lobectomy with central/cervical lymph node dissection were included in the study. Clinical features (age, gender, preoperative/postoperative clinical, and laboratory findings) and histopathological features (histological variant, tumor size, focality, extrathyroidal extension, tumor border, lateral tubular growth, intraglandular dissemination, stromal and lymphocytic tumor response, lymphocytic thyroiditis, lymphovascular invasion, lymph node metastasis, number of metastatic lymph nodes, extranodal extension, size of the metastatic foci) were evaluated. Male gender, conventional variant, tumor size greater than 10 mm, multifocality, extrathyroidal extension, lateral tubular growth, intraglandular dissemination, lymphocytic and stromal tumor response, and absence of lymphocytic thyroiditis were predictive, and older age (>= 45 years) and follicular variant PTC were protective for lymph node metastasis. In order to optimize the management of papillary thyroid carcinomas, pathologists should search for the clues of lymph node metastasis particularly intraglandular dissemination, lateral tubular growth, tumor border and lymphocytic/stromal tumor response, multifocality, concomitant lymphocytic thyroiditis besides the actual prognostic criteria especially in younger aged male patients.en_US
dc.identifier.doi10.1007/s12022-015-9382-7
dc.identifier.endpage228en_US
dc.identifier.issn1046-3976
dc.identifier.issn1559-0097
dc.identifier.issue3en_US
dc.identifier.pmid26209182en_US
dc.identifier.scopus2-s2.0-84938747029en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://doi.org/10.1007/s12022-015-9382-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23015
dc.identifier.volume26en_US
dc.identifier.wosWOS:000358781300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofEndocrine Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectClinicopathological Predictorsen_US
dc.subjectLymph Nodemetastasisen_US
dc.subjectStromal Tumor Reactionen_US
dc.subjectLymphocytic Tumor Reactionen_US
dc.subjectChronic Lymphocytic Thyroiditisen_US
dc.subjectRegulatory T-Cellsen_US
dc.subjectPrognostic-Significanceen_US
dc.subjectCanceren_US
dc.subjectRisken_US
dc.subjectFrequencyen_US
dc.subjectSizeen_US
dc.titleHistopathological Evidence of Lymph Node Metastasis in Papillary Thyroid Carcinomaen_US
dc.typeArticleen_US

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