Effect of psychological stress on the L-arginine-nitric oxide pathway and semen quality

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dc.contributor.authorEskiocak, S.
dc.contributor.authorGozen, A. S.
dc.contributor.authorTaskiran, A.
dc.contributor.authorKilic, A. S.
dc.contributor.authorEskiocak, M.
dc.contributor.authorGulen, S.
dc.date.accessioned2024-06-12T11:13:06Z
dc.date.available2024-06-12T11:13:06Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt has been reported that mental stress causes abnormality of spermiogram parameters. We investigated the effect of psychological stress on the L-arginine-nitric oxide (NO) pathway. Semen samples were collected from 29 healthy fourth semester medical students just before (stress) and 3 months after (non-stress) the final examinations. Psychological stress was measured by the State Anxiety Inventory questionnaire. After standard semen analysis, arginase activity and NO concentration were measured spectrophotometrically in the seminal plasma. Measurements were made in duplicate. During the stress period, Sperm concentration (41.28 +/- 3.70 vs 77.62 +/- 7.13 x 10(6)/mL), rapid progressive motitity of spermatozoa (8.79 +/- 1.66 vs 20.86 +/- 1.63%) and seminal plasma arginase activity (0.12 +/- 0.01 vs 0.22 +/- 0.01 U/mL) were significantly lower than in the non-stress situation, whereas seminal plasma NO (17.28 +/- 0.56 vs 10.02 +/- 0.49 mu mol/L) was higher compared to the non-stress period (P < 0.001 for all). During stress there was a negative correlation between NO concentration and sperm, concentration, the percentage of rapid progressive motility and arginase activity (r = -0.622, P < 0.01; r = -0.425, P < 0.05 and r = -0.445, P < 0.05, respectively). These results indicate that psychological stress causes an increase of NO level and a decrease of arginase activity in the L-arginine-NO pathway. Furthermore, poor sperm quality may be due to excessive production of NO under psychological stress. In the light of these results, we suggest that the arginine-NO pathway, together with arginase and NO synthase, are involved in semen quality under stress conditions.en_US
dc.identifier.doi10.1590/S0100-879X2006000500003
dc.identifier.endpage588en_US
dc.identifier.issn0100-879X
dc.identifier.issn1414-431X
dc.identifier.issue5en_US
dc.identifier.pmid16648894en_US
dc.identifier.scopus2-s2.0-33646429764en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage581en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2006000500003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23420
dc.identifier.volume39en_US
dc.identifier.wosWOS:000237790100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal Of Medical And Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPsychological Stressen_US
dc.subjectArginaseen_US
dc.subjectNitric Oxideen_US
dc.subjectSperm Motilityen_US
dc.subjectSperm Counten_US
dc.subjectArginase Activityen_US
dc.subjectHuman Spermatozoaen_US
dc.subjectDistressen_US
dc.subjectPeroxynitriteen_US
dc.subjectInfertilityen_US
dc.subjectFertilityen_US
dc.subjectMotilityen_US
dc.subjectProducten_US
dc.titleEffect of psychological stress on the L-arginine-nitric oxide pathway and semen qualityen_US
dc.typeArticleen_US

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