Vitamin E modulates apoptosis and c-jun N-terminal kinase activation in ovarian torsion-detorsion injury

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authoridUz, Yesim/0000-0002-0381-4590
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorInan, Mustafa
dc.contributor.authorOmurlu, Imran Kurt
dc.contributor.authorCerkezkayabekir, Aysegul
dc.contributor.authorKizilay, Gulnur
dc.date.accessioned2024-06-12T11:16:30Z
dc.date.available2024-06-12T11:16:30Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the role of vitamin E in follicular degeneration and to assess histopathological and biochemical changes following ischemia-reperfusion (IR) injury in rat ovaries. Twenty-eight Wistar albino rats were randomly divided into four groups: sham, 4 h torsion, 24 h detorsion, and a vitamin E group. Thirty minutes before detorsion, a single dose of 200 mg/kg vitamin E was administered intraperitoneally. The ovarian histology score was determined, serum levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were measured. The apoptosis of granulosa cells and the phospho-c-jun N-terminal kinase (p-JNK) and phospho-p38 (p-p38) immunoreactivities of these cells were determined. MDA and MPO levels were significantly increased in the torsion and detorsion groups. Hemorrhage, edema, and congestion were also apparent in these groups. In addition, the apoptotic index and the immunoreactivity of p-JNK were highest in the detorsion group, which also showed marked follicular degeneration. However, p-p38 activity was not affected by torsion-detorsion (TD) induction. Vitamin E ameliorated TD-induced histological alterations. It also decreased serum levels of MDA and MPO, reduced the activity of p-JNK in the ovaries, and reduced numbers of apoptotic follicular cells. In conclusion, these data indicate that vitamin E attenuated ovarian follicular degeneration by inhibiting the immunoreactivity of p-JNK and reducing the apoptosis of granulosa cells. (c) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkey [2011-121]en_US
dc.description.sponsorshipThe authors acknowledge Trakya University Research Center, Edirne, Turkey for the financial support (project no: 2011-121).en_US
dc.identifier.doi10.1016/j.yexmp.2013.07.007
dc.identifier.endpage219en_US
dc.identifier.issn0014-4800
dc.identifier.issn1096-0945
dc.identifier.issue2en_US
dc.identifier.pmid23911905en_US
dc.identifier.scopus2-s2.0-84882937508en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1016/j.yexmp.2013.07.007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24346
dc.identifier.volume95en_US
dc.identifier.wosWOS:000325674400015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofExperimental And Molecular Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTorsion-Detorsionen_US
dc.subjectApoptosisen_US
dc.subjectJNK MAPKen_US
dc.subjectVitamin Een_US
dc.subjectOvaryen_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectReduces Tissue-Damageen_US
dc.subjectAdnexal Torsionen_US
dc.subjectOxidative Stressen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectGranulosa-Cellsen_US
dc.subjectProtein-Kinaseen_US
dc.subjectRat Ovaryen_US
dc.subjectHistopathologic Evaluationen_US
dc.subjectProinflammatory Cytokinesen_US
dc.titleVitamin E modulates apoptosis and c-jun N-terminal kinase activation in ovarian torsion-detorsion injuryen_US
dc.typeArticleen_US

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