Assessing the Effect of Various Blood Glucose Levels on 18F-FDG Activity in the Brain, Liver, and Blood Pool

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorSarikaya, Ali
dc.contributor.authorSharma, Prem
dc.date.accessioned2024-06-12T10:54:53Z
dc.date.available2024-06-12T10:54:53Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractStudies have extensively analyzed the effect of hyperglycemia on F-18-FDG uptake in normal tissues and tumors. In this study, we measured SUV in the brain, liver, and blood pool in normoglycemia, hyperglycemia, and hypoglycemia to understand the effect of blood glucose on F-18-FDG uptake and to develop a formula to correct SUV. Methods: Whole-body F-18-FDG PET/CT images of adults were selected for analysis. Brain SUVmax, blood-pool SUVmean, and liver SUVmean were measured at blood glucose ranges of 61-70, 71-80, 81-90, 91-100, 101-110, 111-120, 121-130, 131-140, 141-150, 151-160, 161-170, 171-180, 181-190, 191-200, and 201 mg/dL and above. At each blood glucose range, 10 PET images were analyzed (total, 150). The mean (+/- SD) SUV of the brain, liver, and blood pool at each blood glucose range was calculated, and blood glucose and SUV curves were generated. Because brain and tumors show a high expression of glucose transporters 1 and 3, we generated an SUV correction formula based on percentage reduction in brain SUVmax with increasing blood glucose level. Results: Mean brain SUVmax gradually decreased with increasing blood glucose level, starting after a level of 110 mg/dL. The approximate percentage reduction in brain SUV max was 20%, 35%, 50%, 60%, and 65% at blood glucose ranges of 111-120, 121-140, 141-160, 161-200, and 201 mg/dL and above, respectively. In the formula we generated, measured SUV max is multiplied by a reduction factor of 1.25, 1.5, 2, 2.5, and 2.8 for the blood glucose ranges of 111-120, 121-140, 141-160, 161-200, and 201 mg/dL and above, respectively, to correct SUV. Brain SUV max did not differ between hypoglycemic and normoglycemic patients (P > 0.05). SUVmean in the blood pool and liver was lower in hypoglycemic patients (P < 0.05) and did not differ between hyperglycemic (P > 0.05) and normoglycemic patients. Conclusion: Hyperglycemia gradually reduces brain F-18-FDG uptake, starting after a blood glucose level of 110 mg/dL. Hyperglycemia does not affect F-18-FDG activity in the liver or blood pool. Hypoglycemia does not seem to affect brain F-18-FDG uptake but appears to reduce liver and blood-pool activity. The simple formula we generated can be used to correct SUV in hyperglycemic adults in selected cases.en_US
dc.identifier.doi10.2967/jnmt.119.226969
dc.identifier.endpage318en_US
dc.identifier.issn0091-4916
dc.identifier.issn1535-5675
dc.identifier.issue4en_US
dc.identifier.pmid31182660en_US
dc.identifier.scopus2-s2.0-85076125947en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.2967/jnmt.119.226969
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19198
dc.identifier.volume47en_US
dc.identifier.wosWOS:000500933700013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Nuclear Medicine Incen_US
dc.relation.ispartofJournal Of Nuclear Medicine Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood Glucoseen_US
dc.subjectF-18-FDGen_US
dc.subjectBrainen_US
dc.subjectLiveren_US
dc.subjectBlood Poolen_US
dc.subjectPositron-Emission-Tomographyen_US
dc.subjectStandardized Uptake Valuesen_US
dc.subjectFdg-Peten_US
dc.subjectPediatric-Patientsen_US
dc.subjectDiabetes Affecten_US
dc.subjectHyperglycemiaen_US
dc.subjectCanceren_US
dc.subjectTransportersen_US
dc.subjectBiodistributionen_US
dc.subjectEanmen_US
dc.titleAssessing the Effect of Various Blood Glucose Levels on 18F-FDG Activity in the Brain, Liver, and Blood Poolen_US
dc.typeArticleen_US

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