ANTIFUNGAL SUSCEPTIBILITIES OF ASPERGILLUS SPP. STRAINS ISOLATED FROM INVASIVE ASPERGILLOSIS CASES

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dc.authoridEner, Beyza/0000-0002-4803-8206
dc.authoridGurcan, Saban/0000-0002-5052-481X
dc.authorwosidEner, Beyza/AAG-8523-2021
dc.authorwosidGurcan, Saban/D-2754-2017
dc.contributor.authorGurcan, Saban
dc.contributor.authorTikvesli, Melek
dc.contributor.authorEryildiz, Canan
dc.contributor.authorEvci, Canan
dc.contributor.authorEner, Beyza
dc.date.accessioned2024-06-12T10:52:36Z
dc.date.available2024-06-12T10:52:36Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAspergillus species found abundantly in the outer environment and hospital setting may lead to serious morbidity and mortality particularly in patients with suppressed immunity This retrospective study was aimed to investigate the antifungal susceptibilities of Aspergillus spp isolated from aspergillosis cases being hospitalized Aspergillus spp. isolated from samples of the patients with suspected fungal infections between January of 2002 and October of 2007, were investigated A total of 678 samples (420 lower respiratory tract, 202 sterile body fluids, and 56 biopsy/tissue specimens) from 569 patients were included in the study. The samples were incubated in 25 degrees C and 35 degrees C on brain-heart-infusion agar supplemented with blood and on Sabouraud dextrose agar Gram and Giemsa stained samples were also examined by microscopy Mold type of fungi were identified by conventional techniques Invasive aspergillosis was described according to criteria of Invasive Fungal Infections Cooperative Group of the European Organization for Research and Treatment of Cancer. A.fumigatus (n= 8), A.flavus (n= 2) and A niger (n= 2) were isolated from 12 patients' samples (2.1%), 9 of them were lower respiratory tract and one of each was ascid, brain biopsy and pleural fluid specimens. All of those patients have had an underlying diseases such as malignancy The susceptibility of the isolates to caspofungin, voriconazole, itraconazole and amphotericin B was tested by broth microdilution susceptibility testing and to posaconazole by E-test (AB Biodisk, Sweden). The lowest minimum inhibitory concentration (MIC) (<= 0.125 mu g/ml) values were detected for caspofungin and posaconazole for Aspergillus spp, however, the highest MIC values were detected for amphotericin B (> 1 mu g/ml) MIC values of the all strains except one, were detected as <= 0 5 mu g/ml for voriconazole and itraconazole In one A niger strain itraconazole MIC value was 2 mu g/ml Since the number of other species was low, MIC(50) value was determined only for A fumigatus strains and it was found that the highest MIC(50) value was for amphotericin B (2 mu g/ml) and the lowest MIC(50) values were for posaconazole (0.064 mu g/ml), caspofungin (0 064 mu g/ml), itraconazol (0 25 mu g/ml) and voriconazol (0.25 mu g/ml). Since caspofungin and posaconazole revealed the lowest MIC values, they should be taken into consideration in choice of therapy of aspergillosis cases in our hospital.en_US
dc.identifier.endpage278en_US
dc.identifier.issn0374-9096
dc.identifier.issue2en_US
dc.identifier.pmid20549962en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18774
dc.identifier.volume44en_US
dc.identifier.wosWOS:000277896300013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAspergillosisen_US
dc.subjectAspergillus Sppen_US
dc.subjectAntifungal Susceptibilityen_US
dc.subjectMicrodilutionen_US
dc.subjectFungal-Infectionsen_US
dc.subjectItraconazoleen_US
dc.titleANTIFUNGAL SUSCEPTIBILITIES OF ASPERGILLUS SPP. STRAINS ISOLATED FROM INVASIVE ASPERGILLOSIS CASESen_US
dc.typeArticleen_US

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