Chronic lymphocytic leukemia in Turkey

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dc.authoridFerhanoglu, Burhan/0000-0002-4257-549X
dc.authorwosidSoysal, Teoman/C-8223-2017
dc.contributor.authorPamuk, ON
dc.contributor.authorPamuk, GE
dc.contributor.authorSoysal, T
dc.contributor.authorÖngören, N
dc.contributor.authorBaslar, ZB
dc.contributor.authorFerhanoglu, B
dc.contributor.authorAydin, Y
dc.date.accessioned2024-06-12T10:56:30Z
dc.date.available2024-06-12T10:56:30Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: In this study, the clinical characteristics, survival, and prognostic factors of 200 patients diagnosed as having chronic lymphocytic leukemia (CLL) were analyzed. Methods: The medical charts of 200 CLL patients registered to our center between 1984 and 2000 were retrospectively evaluated. stage patients, was shorter than that in other CLL series of Western origin. Rai's staging system was seen to determine prognosis better than Binet's staging system. Results: Of all patients, 129 were men and 71 were women (male/female ratio, 1.82). The median age at the time of initial diagnosis was 63 years (range, 38-90 years). Sixty patients were classified as Binet's Stage A, 49 as Stage B, and 91 as Stage C. Sixty-two cases were diagnosed during routine laboratory examinations when they were asymptomatic. Forty-three patients were lost to follow-up, and 157 patients have been followed regularly until the end of the study period. Hemolytic anemia developed in nine (5.7%) patients, second primary cancer in six (3.8%), and Richter's syndrome in two (1.2%). Forty-eight percent of CLL patients were treated immediately after initial diagnosis. The overall response (complete or partial) to first-line and second-line therapies was 61.6% and 54.4%, respectively. The median time of follow-up for patients followed up regularly was 47 months (range, 1-195 months). Sixty-three patients died during the follow-up: the deaths of 39 (62%) of these were attributable to CLL-related causes. The median survival time was 48 months. The 5-year survival rate was 36.5% and the 10-year survival rate was 8%. Stage according to Rai's classification, lymphocyte count, and age showed a significant prognostic effect on survival by univariate analysis. On multivariate analysis, advanced age and lymphocyte count were independent prognostic parameters. Conclusion: In our study, more asymptomatic CLL patients have been diagnosed in recent years. The survival, especially of our early-stage patients, was shorter than that in other CLL series of Western origin. Rai's staging system was seen to determine prognosis better than Binet's staging system.en_US
dc.identifier.doi10.1097/01.SMJ.0000053674.03385.B7
dc.identifier.endpage245en_US
dc.identifier.issn0038-4348
dc.identifier.issn1541-8243
dc.identifier.issue3en_US
dc.identifier.pmid15043330en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.1097/01.SMJ.0000053674.03385.B7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19802
dc.identifier.volume97en_US
dc.identifier.wosWOS:000222171900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofSouthern Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Lymphocytic Leukemiaen_US
dc.subjectSurvivalen_US
dc.subjectPrognosisen_US
dc.subjectRai's Classificationen_US
dc.subjectBinet's Classificationen_US
dc.subjectMultivariate Survival Analysisen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectPatternen_US
dc.subjectCllen_US
dc.titleChronic lymphocytic leukemia in Turkeyen_US
dc.typeArticleen_US

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