Relationship between insulin resistance assessed by HOMA-IR and exercise test variables in asymptomatic middle-aged patients with Type 2 diabetes

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorUgur-Altun, B
dc.contributor.authorAltun, A
dc.contributor.authorTatli, E
dc.contributor.authorArikan, E
dc.contributor.authorTugrul, A
dc.date.accessioned2024-06-12T11:16:51Z
dc.date.available2024-06-12T11:16:51Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description194th Meeting of the Society-for-Endocrinology -- NOV, 2003 -- London, ENGLANDen_US
dc.description.abstractWe investigated the relationship between index of insulin resistance (IR) and exercise test variables in middle-aged asymptomatic patients with Type 2 diabetes. Methods: 90 patients (48 men, 42 women; age: 49+/-6 yr) were included in the study. We used homeostasis model assessment for IR (HOMA-IR) index as index of IR. All patients were subjected to treadmill exercise test. Four subjects were tested positive (4.4%). Study patients were separated into three groups: group I (no.=26) HOMA-IR index <2.24; group II (no.=26) index 2.24-3.59; group III (no.=38) index >3.59. Results: group I had less frequency of cardiovascular risk factors than group II and III (p=0.001). Systolic blood pressure baseline as well as peak exercise values, were higher in group III than in group I and II (p=0.048 vs p=0.01, respectively). Higher total exercise time and peak workload were found in group I than group II and III (p=0.04). The recovery of heart rate (Delta HRpr) was similar among the study groups. We found significant negative correlations between HOMA-IR and total exercise time and peak workload. In addition we found significant negative correlations between age vs chronotrophic index (CI), Delta HRpr, and peak workload. There were also similar negative correlations between duration of diabetes vs CI and Delta HRpr. Conclusions: IR is associated with a variety of cardiovascular risk factors. Some exercise test variables point out changes of autonomic tone during exercise in elevated IR group. Negative correlation between HOMA-IR and peak exercise capacity (METs) may well confirm increased mortality in hyperinsulinemia. (C) 2004, Editrice Kurtis.en_US
dc.description.sponsorshipSoc Endocrinolen_US
dc.identifier.doi10.1007/BF03345291
dc.identifier.endpage461en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue5en_US
dc.identifier.pmid15279079en_US
dc.identifier.scopus2-s2.0-3242660795en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage455en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345291
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24481
dc.identifier.volume27en_US
dc.identifier.wosWOS:000222246300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2en_US
dc.subjectAdult Diabetesen_US
dc.subjectInsulin Resistanceen_US
dc.subjectExercise Stressen_US
dc.subjectAutonomic Nervous Systemen_US
dc.subjectHeart-Rate Recoveryen_US
dc.subjectHomeostasis Model Assessmenten_US
dc.subjectAutonomic Nervous-Systemen_US
dc.subjectPrognostic Valueen_US
dc.subjectChronotropic Incompetenceen_US
dc.subjectSubmaximal Exerciseen_US
dc.subjectRate-Variabilityen_US
dc.subjectRate Responseen_US
dc.subjectFollow-Upen_US
dc.subjectAll-Causeen_US
dc.titleRelationship between insulin resistance assessed by HOMA-IR and exercise test variables in asymptomatic middle-aged patients with Type 2 diabetesen_US
dc.typeConference Objecten_US

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