A study to enhance the oral bioavailability of s-adenosyl-L-methionine (SAMe): SLN and SLN nanocomposite particles

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dc.authoridAmasya, Gülin/0000-0002-0491-450X
dc.authoridYuksel, Nilufer/0000-0002-8907-9741
dc.authoridsezgin bayindir, zerrin/0000-0002-0386-7887
dc.authoridErgin, Ahmet Dogan/0000-0002-9387-0085
dc.authorwosidAmasya, Gülin/AAC-4141-2020
dc.authorwosidYuksel, Nilufer/AAH-2604-2020
dc.authorwosidErgin, Ahmet Dogan/AAO-1876-2021
dc.authorwosidsezgin bayindir, zerrin/HCI-2395-2022
dc.contributor.authorAmasya, Gulin
dc.contributor.authorErgin, Ahmet Dogan
dc.contributor.authorCakirci, Ozge Erkan
dc.contributor.authorOzcelikay, Arif Tanju
dc.contributor.authorBayindir, Zerrin Sezgin
dc.contributor.authorYuksel, Nilufer
dc.date.accessioned2024-06-12T11:13:52Z
dc.date.available2024-06-12T11:13:52Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe endogenous molecule, S-adenosyl-L-methionine (SAMe) is a key factor due to its role in the methylation cycle and modulation of monoaminergic neurotransmission. Since many mental disorders have linked to the monoaminergic system, the level of SAMe in blood and cerebrospinal fluid is important in the treatment of major depression. In this study, solid lipid nanoparticles (SLN) were prepared in order to increase the limited oral bioavailability of SAMe, and SLN based nanocomposite particles (SAMe-SLN-NC) were further developed using an enteric polymer for passive targeting of intestinal lymphatic system. In this manner, it was also aimed to protect SAMe loaded SLN from harsh gastric environment as well as hepatic first-pass metabolism. Dynamic light scattering (DLS) analysis of SLN was performed, drug content was measured, SAMe release patterns were examined and the permeation ability of SAMe was investigated by the Parallel Artificial Membrane Permeability Assay (PAMPA) to characterize SAMe loaded SLN formulation. According to the PAMPA results, SAMe-SLN with the average particle size of 242 nm showed enhanced SAMe permeability in comparison to pure drug. Delayed drug release obtained by SLN nanocomposite particles indicated the protection of drug-loaded SLN in the acidic gastric medium and their intact presence in the intestine. SAMe solution or particle suspensions were prepared using 0.45 (w/v) hydroxypropyl methylcellulose aqueous solution to be applied to groups of animals for pharmacokinetic studies. In vivo pharmacokinetic parameters revealed enhancement in relative bioavailability of SAMe upon oral administration of SLN based formulations. This was attributed to intact absorption of lipid matrix through lymphatic path. A statistically significant increase in SAMe plasma levels was obtained at 15th and 30th minutes with SAMe-SLN and at 2nd and 4th hours with SAMe-SLN-NC. Overall results suggest that SLN is a promising carrier to passive lymphatic targeting of SAMe and novel SLN nanocomposite particles which presented efficient oral bioavailability is a potential way for oral delivery of SAMe and treatment of major depression.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [115 S 339]en_US
dc.description.sponsorshipThis study was supported by TUBITAK (The Scientific and Technological Research Council of Turkey) under grant 115 S 339.en_US
dc.identifier.doi10.1016/j.chemphyslip.2021.105086
dc.identifier.issn0009-3084
dc.identifier.issn1873-2941
dc.identifier.pmid33930379en_US
dc.identifier.scopus2-s2.0-85105323520en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.chemphyslip.2021.105086
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23692
dc.identifier.volume237en_US
dc.identifier.wosWOS:000654168000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofChemistry And Physics Of Lipidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectS-Adenosyl-L-Methionineen_US
dc.subjectMajor Depressionen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectNanocomposite Particlesen_US
dc.subjectOral Bioavailabilityen_US
dc.subjectSolid-Lipid Nanoparticlesen_US
dc.subjectControlled Drug-Deliveryen_US
dc.subjectAdenosylmethionineen_US
dc.subjectFormulationen_US
dc.subjectReleaseen_US
dc.subjectOptimizationen_US
dc.subjectAugmentationen_US
dc.subjectPermeabilityen_US
dc.subjectSolubilityen_US
dc.subjectDepressionen_US
dc.titleA study to enhance the oral bioavailability of s-adenosyl-L-methionine (SAMe): SLN and SLN nanocomposite particlesen_US
dc.typeArticleen_US

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