The effects of taking chronic nitrate by drinking water on thyroid functions and morphology

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dc.authoridDündar, Cihad/0000-0001-9658-2540
dc.authorwosidDündar, Cihad/A-1148-2013
dc.contributor.authorEskiocak, S
dc.contributor.authorDundar, C
dc.contributor.authorBasoglu, T
dc.contributor.authorAltaner, S
dc.date.accessioned2024-06-12T10:59:53Z
dc.date.available2024-06-12T10:59:53Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNitrate incorporation in humans takes place via drinking water and food. The water used for drinking and cooking in the goitrous areas is high in nitrate content. The aim of the present study was to evaluate both chronic effects and the dose-response relationship of nitrate on thyroid functions. A total of rats were divided into 5 work groups and sodium nitrate was added to their drinking water in different concentrations (0, 50, 100, 250 and 500 mg/l) over a 30-week period. The radioiodine uptake of thyroid was decreased in the 50 mg/l nitrate group, whereas it was increased in the 250 and 500 mg/l nitrate groups as compared to control. All hormones of thyroid gland except total thyroxine and thyroid-stimulating hormone were decreased in the 50, 250 and 500 mg/l nitrate groups. However, the level of total thyroxin was increased in the 100 mg/l nitrate group. Thyroid gland weights were increased in all experimental groups. Histomorphological changes were observed in the 250 and 500 mg/l nitrate groups. These findings suggest that nitrate impairs thyroid function involving the hypothalamo-hypophysio-thyroid axis. This observation could contribute to the current discussion about the acceptable daily intake of nitrate, as well as drinking water nitrate standard safety margins.en_US
dc.identifier.doi10.1007/s10238-005-0068-1
dc.identifier.endpage71en_US
dc.identifier.issn1591-8890
dc.identifier.issue2en_US
dc.identifier.pmid16096856en_US
dc.identifier.scopus2-s2.0-23844531499en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.1007/s10238-005-0068-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20593
dc.identifier.volume5en_US
dc.identifier.wosWOS:000230928700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofClinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrinking Wateren_US
dc.subjectNitrateen_US
dc.subjectThyroid Functionen_US
dc.subjectRadioiodine Uptakeen_US
dc.subjectThyroid Weighten_US
dc.subjectThyroid Morphologyen_US
dc.subjectDietary Nitrateen_US
dc.subjectLead Nitrateen_US
dc.subjectSomatomedinen_US
dc.subjectGrowthen_US
dc.subjectLevelen_US
dc.titleThe effects of taking chronic nitrate by drinking water on thyroid functions and morphologyen_US
dc.typeArticleen_US

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