Melatonin administration acutely decreases the diffusing capacity of carbon monoxide in human lungs

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosid, Osman/AGR-7980-2022
dc.authorwosid, osman/HRD-6024-2023
dc.contributor.authorVardar, Selma Arzu
dc.contributor.authorAltun, Guelay Durmus
dc.contributor.authorGuenerbueyuek, Caner
dc.contributor.authorHatipoglu, Osman Nuri
dc.contributor.authorMert, Selva
dc.contributor.authorKaymak, Kadir
dc.date.accessioned2024-06-12T11:08:14Z
dc.date.available2024-06-12T11:08:14Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Most physiological measurements of the pulmonary diffusing capacity use carbon monoxide (CO) as a tracer gas. Similar to CO, melatonin binds the hemoglobin in the blood. Objective: The present study was designed to assess the effect of exogenous melatonin administration on pulmonary functions including diffusing capacity for carbon monoxide (DLCO) in healthy subjects. Methods: The study was performed in a randomized, double-blind, placebo-controlled manner. DLCO was measured in 22 healthy male volunteers ( age 18 - 25 years) who were randomized to melatonin (n = 11) and placebo administration ( n = 11). At baseline, DLCO, alveolar volume (V-A) and other spirometric parameters such as forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and maximal voluntary ventilation (MVV) were measured. DLCO was then corrected for the hemoglobin concentration. Measurements were repeated in a double-blind fashion 60 min after the administration of melatonin ( 1 mg) or placebo. Results: DLCO was significantly decreased (39.31 +/- 4.75 vs. 34.82 +/- 6.18 ml/min/mm Hg) 60 min after the melatonin administration ( p = 0.01), while FEV1, FVC, FEV1/FVC, PEF and MVV values did not demonstrate significant differences. Placebo administration did not result in significant alteration in any of these parameters. Conclusions: In healthy subjects, oral administration of melatonin acutely influences the DLCO without affecting other pulmonary function test results. We conclude that melatonin may have a reducing effect on the DLCO in the lungs. Copyright (C) 2006 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000088686
dc.identifier.endpage513en_US
dc.identifier.issn0025-7931
dc.identifier.issn1423-0356
dc.identifier.issue4en_US
dc.identifier.pmid16195665en_US
dc.identifier.scopus2-s2.0-33745212512en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage509en_US
dc.identifier.urihttps://doi.org/10.1159/000088686
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22359
dc.identifier.volume73en_US
dc.identifier.wosWOS:000241775500018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofRespirationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectCarbon Monoxideen_US
dc.subjectDiffusing Capacityen_US
dc.subjectPulmonary Functionen_US
dc.subjectPulmonary-Functionen_US
dc.subjectBinding-Sitesen_US
dc.subjectBlooden_US
dc.subjectVolumeen_US
dc.subjectRatesen_US
dc.subjectHearten_US
dc.titleMelatonin administration acutely decreases the diffusing capacity of carbon monoxide in human lungsen_US
dc.typeArticleen_US

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