Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis

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dc.authoridbozgeyik, ibrahim/0000-0003-1483-2580
dc.authoridDemiryurek, Abdullah/0000-0003-4762-4745
dc.authoridYolbaş, Servet/0000-0001-8516-9769
dc.authoridALIBAZ-ONER, FATMA/0000-0002-6653-1758;
dc.authorwosidbozgeyik, ibrahim/AAI-2723-2020
dc.authorwosidDemiryurek, Abdullah/AAG-5244-2020
dc.authorwosidpehlivan, yavuz/AAG-8227-2021
dc.authorwosidYolbaş, Servet/ABI-5312-2020
dc.authorwosidALIBAZ-ONER, FATMA/AAR-2072-2020
dc.authorwosidDireskeneli, Haner/AAS-5508-2020
dc.contributor.authorOztuzcu, Serdar
dc.contributor.authorOnat, Ahmet M.
dc.contributor.authorPehlivan, Yavuz
dc.contributor.authorAlibaz-Oner, Fatma
dc.contributor.authorDonmez, Salim
dc.contributor.authorCetin, Gozde Y.
dc.contributor.authorYolbas, Servet
dc.date.accessioned2024-06-12T10:55:57Z
dc.date.available2024-06-12T10:55:57Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/Aim: Systemic sclerosis (SSc) is an inflammatory disease characterized by vascular abnormalities and fibrosis. The aim of the present study was to investigate the possible role of transient receptor potential melastatin (TRPM) channel genes in the susceptibility and phenotype expression of SSc. Materials and Methods: A total of 339 patients with SSc and 302 healthy controls were studied. Genomic DNA was extracted from leukocytes of the peripheral blood, and 25 single nucleotide polymorphisms in the TRPM channel genes were analyzed by the BioMark HD dynamic array system. Results: There were marked increases in the CC genotype (94.7% vs 81.8%, p<0.0001) and C allele frequencies (97.0% vs. 90.1%, p<0.0001) in the TRPM3 rs1328142, and TT genotype (19.0% vs. 7.8%, p=0.0002) in TRPM5 rs34551253 (Ala456Thr) polymorphism in SSc patients when compared to controls. TRPM3 gene rs1328142 polymorphism was also markedly associated with disease phenotype. However, no associations with the other 23 polymorphisms studied were found. Conclusion: This is the first study to examine the involvement of TRPM channel gene variations on the risk of SSc incidence. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of SSc in the Turkish population.en_US
dc.identifier.endpage770en_US
dc.identifier.issn0258-851X
dc.identifier.issn1791-7549
dc.identifier.issue6en_US
dc.identifier.pmid26546534en_US
dc.identifier.scopus2-s2.0-84958152831en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19605
dc.identifier.volume29en_US
dc.identifier.wosWOS:000365993400016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.ispartofIn Vivoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCation Channelsen_US
dc.subjectHaplotypeen_US
dc.subjectPolymorphismen_US
dc.subjectSclerodermaen_US
dc.subjectSystemic Sclerosisen_US
dc.subjectTransient Receptor Potential Melastatinen_US
dc.subjectPulmonary Arterial-Hypertensionen_US
dc.subjectSmooth-Muscle-Cellsen_US
dc.subjectOxidative Stressen_US
dc.subjectDisease-Activityen_US
dc.subjectSclerodermaen_US
dc.subjectClassificationen_US
dc.subjectIdentificationen_US
dc.subjectPathogenesisen_US
dc.subjectCriteriaen_US
dc.titleAssociation of TRPM Channel Gene Polymorphisms with Systemic Sclerosisen_US
dc.typeArticleen_US

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