Synthesis methods, characterizations and usage areas of medicinal compounds from THP, and their Ag(I)-NHC complexes, and their antimicrobial efficiencies

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dc.contributor.authorTurkyilmaz, Murat
dc.contributor.authorDonmez, Murat
dc.date.accessioned2024-06-12T10:55:41Z
dc.date.available2024-06-12T10:55:41Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNatural or synthetic substances can be used to create smart medications, which can enhance cognitive performance in healthy individuals. They are frequently used to boost memory, concentration, creativity, intelligence, and motivation in the fiercely competitive world of today.To achieve optimum results, the drug should be applied to the target site at the appropriate concentration, with as few or no adverse effects as possible due to off-target actions. Recent studies have shown that such drugs, which are often used in chemotherapy, can reduce the level of discomfort cancer patients endure. In this study, metal complexes that can carry silver nanoparticles with electrical and optical properties were formed. This article examines the potential of man-made silver N-heterocyclic complexes as smart drugs. Following the synthesis of new carbene species from the Xthantine compound, metal complexes were produced for this use. The chemical structures of these carbenes and metal complexes were investigated using a variety of methods, including melting point studies, conductivity, H-1-NMR and C-13-NMR, LC-Mass, FT-IR, TGA, and UV-vis spectrophotometry. These metal complexes differ mostly due to their solubility in water. Using the disk diffusion method, the antimicrobial and antibacterial properties of silver(I)-NHC complexes were examined against Gram-positive and Gram-negative bacteria as well as fungi. It has been observed that the antimicrobial activity of 7,9-bis(2-cyanoethyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-9-ium silver(I)bromide compound is high. These data suggest that this compound has strong antibacterial properties.en_US
dc.description.sponsorshipTrakya University Research Fund's research grant [TUBAP-2014-106]en_US
dc.description.sponsorshipTrakya University Research Fund's research grant (TUBAP-2014-106) was gratefully accepted.en_US
dc.identifier.doi10.3233/MGC-220121
dc.identifier.endpage567en_US
dc.identifier.issn1024-1221
dc.identifier.issn1745-1167
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85180089987en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage557en_US
dc.identifier.urihttps://doi.org/10.3233/MGC-220121
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19506
dc.identifier.volume22en_US
dc.identifier.wosWOS:001114444300006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofMain Group Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbeneen_US
dc.subjectCandida Albicansen_US
dc.subjectTGA Analysisen_US
dc.subjectAzolium Saltsen_US
dc.subjectMetal Complexesen_US
dc.subjectHeterocyclic Carbene Complexesen_US
dc.subjectAnticancer Activityen_US
dc.subjectTheophyllineen_US
dc.subjectLigandsen_US
dc.subjectDesignen_US
dc.subjectNickelen_US
dc.subjectCellsen_US
dc.titleSynthesis methods, characterizations and usage areas of medicinal compounds from THP, and their Ag(I)-NHC complexes, and their antimicrobial efficienciesen_US
dc.typeArticleen_US

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