Annual trends in antibiotic resistance of nosocomial Acinetobacter baumannii strains and the effect of synergistic antibiotic combinations

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dc.authoridGurcan, Saban/0000-0002-5052-481X
dc.authorwosidGurcan, Saban/D-2754-2017
dc.contributor.authorTatman-Otkun, M
dc.contributor.authorGürcan, S
dc.contributor.authorÖzer, B
dc.contributor.authorShokrylanbaran, N
dc.date.accessioned2024-06-12T10:50:23Z
dc.date.available2024-06-12T10:50:23Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcinetobacter baumannii is becoming increasingly resistant to antibiotics often requiring combination therapy. Annual changes of resistance to selected antimicrobials of 150 A. baumannii strains, isolated as nosocomial pathogens between 1994 and 2000 were investigated. The synergistic effects of antimicrobials were studied using a microdilution checkerboard technique in eight selected isolates resistant to third-generation cephalosporins and beta-lactam/beta-lactamase inhibitor combinations and to at least one aminoglycoside. Rates of resistance of cefepime, ceftazidime, ampicillin/sulbactam, amikacin and ciprofloxacin (before 1996 and between 1996-2000) were 29.7% - 72.6, 37.8% - 81.4%, 35.1% - 72.6%, 8.1% - 56.6%, 5.4% - 46.0% respectively (p<0.001 for each one). Synergy was observed in at least one of the combinations of antibiotics from seven of eight isolates (87%), no antagonism was detected with any combination. Ceftazidime-amikacin (50%) and ampicillin/sulbactam-tobramycin (50%) were the most effective combinations. Due to the effectiveness of sulbactams to Acinetobacter, ampicillin/sulbactam-tobramycin combination is recommended as the first line of choice.en_US
dc.identifier.endpage28en_US
dc.identifier.issn1121-7138
dc.identifier.issue1en_US
dc.identifier.pmid14964402en_US
dc.identifier.scopus2-s2.0-11844275398en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17987
dc.identifier.volume27en_US
dc.identifier.wosWOS:000188654000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLuigi Ponzio E Figlioen_US
dc.relation.ispartofMicrobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectHospital-Acquired Infectionen_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectAntibiotic Synergyen_US
dc.subjectCheckerboarden_US
dc.subjectInfectionsen_US
dc.titleAnnual trends in antibiotic resistance of nosocomial Acinetobacter baumannii strains and the effect of synergistic antibiotic combinationsen_US
dc.typeArticleen_US

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