Does Gender Difference Effect Radiation-Induced Lung Toxicity? An Experimental Study by Genetic and Histopathological Predictors

Basit Öğe Kaydı
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887;
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidDemir, Selma/A-1500-2018
dc.contributor.authorCosar, Rusen
dc.contributor.authorOzen, Alaattin
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSut, Necdet
dc.contributor.authorCakina, Suat
dc.contributor.authorDemir, Selma
dc.contributor.authorParlar, Sule
dc.date.accessioned2024-06-12T11:19:13Z
dc.date.available2024-06-12T11:19:13Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSeveral studies have reported differences in radiation toxicity between the sexes, but these differences have not been tested with respect to histopathology and genes. This animal study aimed to show an association between histopathological findings of radiation-induced lung toxicity and the genes ATM, SOD2, TGF-beta 1, XRCC1, XRCC3 and HHR2. In all, 120 animals were randomly divided into 2 control groups (male and female) and experimental groups comprising fifteen rats stratified by sex, radiotherapy (0 Gy vs. 10 Gy), and time to sacrifice (6, 12, and 24 weeks postirradiation). Histopathological evaluations for lung injury, namely, intra-alveolar edema, alveolar neutrophils, intra-alveolar erythrocytes, activated macrophages, intra-alveolar fibrosis, hyaline arteriosclerosis, and collapse were performed under a light microscope using a grid system; the evaluations were semi quantitatively scored. Then, the alveolar wall thickness was measured. Real-time quantitative reverse transcription PCR (RT-qPCR) was used to determine gene expression differences in ATM, TGF-beta 1, XRCC1, XRCC3, SOD2 and HHR2L among the groups. Histopathological data showed that radiation-induced acute, subacute, and chronic lung toxicity were worse in male rats. The expression levels of the evaluated genes were significantly higher in females than males in the control group, but this difference was lost over time after radiotherapy. Less toxicity in females may be attributable to the fact that the expression of the evaluated genes was higher in normal lung tissue in females than in males and the changes in gene expression patterns in the postradiotherapy period played a protective role in females. Additional data related to pulmonary function, lung weights, imaging, or outcomes are needed to support this data that is based on histopathology alone. (C) 2022 by Radiation Research Societyen_US
dc.identifier.doi10.1667/RADE-21-00075.1
dc.identifier.endpage288en_US
dc.identifier.issn0033-7587
dc.identifier.issn1938-5404
dc.identifier.issue3en_US
dc.identifier.pmid34735567en_US
dc.identifier.scopus2-s2.0-85125852006en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage280en_US
dc.identifier.urihttps://doi.org/10.1667/RADE-21-00075.1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25114
dc.identifier.volume197en_US
dc.identifier.wosWOS:000763750500008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRadiation Research Socen_US
dc.relation.ispartofRadiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIonizing-Radiationen_US
dc.subjectRadiotherapyen_US
dc.subjectCanceren_US
dc.subjectRadiogenomicsen_US
dc.subjectTherapyen_US
dc.subjectPolymorphismsen_US
dc.subjectRadiobiologyen_US
dc.subjectPneumonitisen_US
dc.subjectExpressionen_US
dc.subjectOncologyen_US
dc.titleDoes Gender Difference Effect Radiation-Induced Lung Toxicity? An Experimental Study by Genetic and Histopathological Predictorsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu