Protective Effect of Cannabinoid Receptor-2 Blockage in Experimental Myoglobinuric Acute Kidney Injury

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.contributor.authorErge, Ummuhan
dc.contributor.authorArslan, Enver
dc.contributor.authorDeger, Ecem Busra
dc.contributor.authorKaya, Oktay
dc.contributor.authorMetin, Melike Sapmaz
dc.contributor.authorGunduz, Ozgur
dc.date.accessioned2024-06-12T10:50:33Z
dc.date.available2024-06-12T10:50:33Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Acute kidney injury is an important public health problem worldwide due to the significant morbidities and the economic burden it causes. We aimed to investigate the effects of cannabinoid receptor agonists and antagonists on biochemical and histopathological parameters in myoglobinuric acute kidney injury (MAKI). Methods: Wistar rats were divided into seven groups. Six groups underwent a 50% glycerol injection to establish kidney injury, while one group received physiological saline (PS) injection to serve as a control. Agonist (WIN55,212-2) and antagonist (AM251 or SR144528) injections were administered intraperitoneally at 60-and 75 minutes following glycerol injection. Serum and urine samples were collected, and kidney tissues were removed. Glutathione, malondialdehyde, urea, creatinine, and sodium levels were assayed. Histopathological evaluation was performed semi-quantitatively on the hematoxylin eosin -stained sections. Results: Serum creatinine and urea levels were significantly higher in all kidney injury groups compared to control. Serum creatinine level was significantly lower in the WIN+SR144528 group compared to the AKI group. Histological damage score was significantly lower in the WIN and WIN+SR144528 groups compared to the AKI group. Conclusions: Blockade of cannabinoid 2 receptors improved kidney function and histology against MAKI, while blockade of cannabinoid 1 receptors caused negative results.en_US
dc.identifier.endpage207en_US
dc.identifier.issn0326-3428
dc.identifier.issn2346-8548
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85182215162en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18049
dc.identifier.volume43en_US
dc.identifier.wosWOS:001125156900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsoc Regional Dialisis Trasplantes Renalesen_US
dc.relation.ispartofRevista De Nefrologia Dialisis Y Trasplanteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectCannabinoid Receptorsen_US
dc.subjectOxidative Stressen_US
dc.subjectSR144528en_US
dc.subjectAcute-Renal-Failureen_US
dc.subjectEndocannabinoid Systemen_US
dc.subjectIschemiaen_US
dc.titleProtective Effect of Cannabinoid Receptor-2 Blockage in Experimental Myoglobinuric Acute Kidney Injuryen_US
dc.typeArticleen_US

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