INVESTIGATION OF THE RELATIONSHIP OF TNFRSF11A GENE POLYMORPHISMS WITH BREAST CANCER DEVELOPMENT AND METASTASIS RISK IN PATIENTS WITH BRCA1 OR BRCA2 PATHOGENIC VARIANTS LIVING IN THE TRAKYA REGION OF TURKEY

Basit Öğe Kaydı
dc.authorwosidDemir, Selma/A-1500-2018
dc.authorwosidOZEN, YASEMİN/AEW-9427-2022
dc.contributor.authorOzdemir, K.
dc.contributor.authorGurkan, H.
dc.contributor.authorDemir, S.
dc.contributor.authorAtli, E.
dc.contributor.authorOzen, Y.
dc.contributor.authorSezer, A.
dc.contributor.authorTuncbilek, N.
dc.date.accessioned2024-06-12T10:55:10Z
dc.date.available2024-06-12T10:55:10Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractModifying genes play an exclusive role in the genetic regulation of the risk of breast cancer development in women with a pathogenic variation of BRCA1 or BRCA2. Therefore, it has been suggested that TNFRSF11A, which is among those modifying genes present in breast cancer development, may have a significant role in patients with positive BRCA1 or BRCA2 variations. In our study, we investigated the probable effects of single nucleotide polymorphisms (SNPs) in the TNFRSF11A gene, such as rs4485469, rs9646629, rs34739845, rs17069904, rs 884205, rs4941129 on the risk of breast cancer in patients with BRCA1 or BRCA2 variations. A total of 23 breast cancer patients with pathogenic variations in the BRCA1 or BRCA2 genes, 28 patients with no pathogenic variations in the BRCA1 or BRCA2 genes, and 55 healthy women as a control group, were included in this study. The SNPs were determined with allelic discrimination analysis through the real-time polymerase chain reaction (qPCR) method. There was no statistically significant difference between the SNPs of the TNFRSF11A gene rs4485469, rs9646629, rs34739845, rs17069904, rs884205, rs4941129 and metastasis, estrogen receptor, progesterone receptor and CerB2 receptor positivity between patient and control group (p >0.05). However, the rs4485469 SNP was found to be borderline significant between the patient groups with and without BRCA1 or BRCA2 mutations (p = 0.059). In patients with BRCA1 or BRCA2 pathogenic variations living in the Trakya region of Turkey, we could not determine the relationship between TNFRSF11 SNPs with breast cancer risk.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP-2016-252]en_US
dc.description.sponsorshipThis study was funded by the Trakya University Scientific Research Projects Unit [TUBAP-2016-252].en_US
dc.identifier.doi10.2478/bjmg-2020-0016
dc.identifier.endpage57en_US
dc.identifier.issn1311-0160
dc.identifier.issue2en_US
dc.identifier.pmid33816072en_US
dc.identifier.scopus2-s2.0-85103149486en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.2478/bjmg-2020-0016
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19312
dc.identifier.volume23en_US
dc.identifier.wosWOS:000645002500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMacedonian Acad Sciences Artsen_US
dc.relation.ispartofBalkan Journal Of Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBRCA1en_US
dc.subjectBRCA2en_US
dc.subjectBreast Canceren_US
dc.subjectSingle Nucleotide Polymorphism (SNP)en_US
dc.subjectTNFRSF11A Geneen_US
dc.titleINVESTIGATION OF THE RELATIONSHIP OF TNFRSF11A GENE POLYMORPHISMS WITH BREAST CANCER DEVELOPMENT AND METASTASIS RISK IN PATIENTS WITH BRCA1 OR BRCA2 PATHOGENIC VARIANTS LIVING IN THE TRAKYA REGION OF TURKEYen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu