Association of renal dysfunction with stroke subtypes in acute stroke patients

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dc.authoridkavalcı, cemil/0000-0003-2529-2946
dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authorwosidkavalcı, cemil/AGG-1308-2022
dc.contributor.authorKavalci, C.
dc.contributor.authorGuldiken, B.
dc.contributor.authorUstundag, S.
dc.contributor.authorGuldiken, S.
dc.date.accessioned2024-06-12T10:58:51Z
dc.date.available2024-06-12T10:58:51Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: There are conflicting published data about the association of renal dysfunction with cerebrovascular diseases. Both diseases have shared risk factors such as hypertension, diabetes mellitus and smoking. In the present study, the relationship of renal dysfunction with stroke subtypes and stroke severity was investigated. Materials and methods: One hundred and sixty-two acute stroke patients without known history of renal disease and 148 control subjects were enrolled in the study. Serum urea, serum creatinine level and glomerular filtration rate (GFR) as estimated by the Modification of Diet in Renal Disease formula were used to evaluate renal dysfunction. Stroke patients were divided into two groups as haemorrhagic and ischemic stroke, the latter being further subdivided into small and large vessel disease subtypes according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria. Stroke severity was assessed by the modified Rankin Scale. Results: Serum creatinine and urea levels were significantly higher and GFR was significantly lower in the stroke group than the controls (p<0.001, p<0.001, p<0.001, respectively). Serum creatinine level was found significantly higher in haemorrhagic stroke than ischaemic stroke subtypes (p<0.001). There was no difference between ischemic subtypes regarding the measured renal parameters. Stroke severity correlated with increased creatinine levels (p<0.001, beta=0.404, 95% CI=1.85-3.50). Conclusion: Acute stoke patients have impaired renal function. Renal dysfunction is particularly more prominent in haemorrhagic stroke and exists probably prior to the stroke. Whether renal dysfunction is an independent risk factor for stroke needs to be clarified by large population studies. (Hong Kong j.emerg.med. 20 10; 17:22-26)en_US
dc.identifier.doi10.1177/102490791001700104
dc.identifier.endpage26en_US
dc.identifier.issn1024-9079
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-75749110187en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.1177/102490791001700104
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20210
dc.identifier.volume17en_US
dc.identifier.wosWOS:000273600800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedcom Ltden_US
dc.relation.ispartofHong Kong Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCreatinineen_US
dc.subjectGlomerular Filtration Rateen_US
dc.subjectRenal Insufficiencyen_US
dc.subjectStrokeen_US
dc.subjectChronic Kidney-Diseaseen_US
dc.subjectGlomerular-Filtration-Rateen_US
dc.subjectAcute Ischemic-Strokeen_US
dc.subjectRisk-Factoren_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectPopulationen_US
dc.subjectMortalityen_US
dc.subjectFatalityen_US
dc.subjectEventsen_US
dc.subjectTrialen_US
dc.titleAssociation of renal dysfunction with stroke subtypes in acute stroke patientsen_US
dc.typeArticleen_US

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