Association of Changes in Thickness of Limbal Epithelial and Stroma with Corneal Scars Detected by High-Resolution Anterior Segment Optic Coherence Tomography

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dc.contributor.authorGuclu, Hande
dc.contributor.authorSattarpanah, Samira
dc.contributor.authorGurlu, Vuslat
dc.date.accessioned2024-06-12T10:58:34Z
dc.date.available2024-06-12T10:58:34Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim To investigate the corneal central and limbal thickness in cornea scar patients using high-resolution anterior segment optical coherence tomography (AS-OCT) and to determine the changes in the limbal region due to the corneal scar. Also, to evaluate tear film parameters in scar patients. Methods Thirty patients with central corneal scar and 30 control subjects. The control subjects were healthy individuals who came to our clinic for routine ophthalmological examination. They were enrolled in this matched case-control study. Central epithelial thickness (ET), stromal thickness (ST), limbal epithelial thickness (LET), and limbal stromal thickness (LST) were analyzed using high-resolution AS-OCT. For evaluation of the ocular surface, the following techniques were used: tear break-up time (BUT) employing standard sterile strips of fluorescein sodium, Schirmer test- I (SCH), and the Ocular Surface Disease Index (OSDI) Questionnaire. Results The mean central ET of the patient group was 51.5 +/- 12.4 mu m, while the mean central ET of the control group was 59.2 +/- 9.0 mu m. There was a statistically significant difference between patients and controls (p = 0.008). The mean LST of the patients was 747.9 +/- 115.7 mu m, and the mean LST of the controls was 726.3 +/- 79.7 mu m. There was a statistically significant difference between patients and controls according to BUT (p = 0.009) and SCH (p = 0.04). However, there was no significant difference between OSDI results of patients and controls (p = 0.08). Conclusion Corneal monitoring with high-resolution AS-OCT is a simple, noninvasive, useful technique for corneal scar patients. Cornea scars cause decreased ET. This result could be associated with lower tear film parameters in scar patients. The scar length is associated with higher intraocular pressure (IOP) values. Decreased LET and increased LST were detected in scar patients.en_US
dc.identifier.doi10.1055/a-1842-2683
dc.identifier.issn0023-2165
dc.identifier.issn1439-3999
dc.identifier.pmid35504299en_US
dc.identifier.scopus2-s2.0-85167650858en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1055/a-1842-2683
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20101
dc.identifier.wosWOS:001040673700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofKlinische Monatsblatter Fur Augenheilkundeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneaen_US
dc.subjectInformation Technologyen_US
dc.subjectAnatomyen_US
dc.subjectTear Functionen_US
dc.subjectKeratitisen_US
dc.subjectFibrosisen_US
dc.subjectLasiken_US
dc.titleAssociation of Changes in Thickness of Limbal Epithelial and Stroma with Corneal Scars Detected by High-Resolution Anterior Segment Optic Coherence Tomographyen_US
dc.typeArticleen_US

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