Effect of curcumin on ipsilateral and contralateral testes after unilateral testicular torsion in a rat model

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorYalcin, Omer
dc.contributor.authorInan, Mustafa
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorTuran, Nesrin
dc.date.accessioned2024-06-12T11:16:56Z
dc.date.available2024-06-12T11:16:56Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to determine the protective effect of curcumin on testicular ischemia- reperfusion ( I/ R) injury. Materials and Methods: 32 male rats were divided into four groups ( n = 8): group 1: control; group 2: ischemia; group 3: I/ R, and group 4: I/ R+CUR. Curcumin ( 150 mg/ kg, p. o.) was administered before 30 min of reperfusion in group 4. Malondialdehyde ( MDA) levels, Johnsen's testicular biopsy scores, and mean seminiferous tubule diameter measurements were evaluated in testes. In addition, endothelial nitric oxide synthase ( eNOS) and inducible nitric oxide synthase ( iNOS) expressions were evaluated immunohistochemically. Results: MDA levels in control groups were significantly lower than other groups in ipsilateral and contralateral testes. Johnsen's scores in the control group were significantly higher than in other groups. MDA levels and Johnsen's scores in the I/ R+ CUR group were similar to the ischemia and I/ R groups in ipsilateral and contralateral testes. The immunoreactivity of iNOS and eNOS were increased in I/ R ipsilateral testicular groups. After I/ R, iNOS and eNOS expression increased slightly in contralateral groups. Additionally, the curcumin treatment decreased iNOS and eNOS immunoreactivity in ipsilateral and contralateral testes. Conclusion: The results suggest that curcumin did not protect the unilateral nor contralateral testes. This observation may depend on inhibition of iNOS and eNOS due to inhibition of the antioxidant, anti- inflammatory effects of nitric oxide. Copyright (C) 2008 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000112614
dc.identifier.endpage207en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue2en_US
dc.identifier.pmid18362493en_US
dc.identifier.scopus2-s2.0-41149174569en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.1159/000112614
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24494
dc.identifier.volume80en_US
dc.identifier.wosWOS:000254155400016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUnilateral Testicular Torsionen_US
dc.subjectCurcumin, Protective Effecten_US
dc.subjectTesticular Ischemia-Reperfusion Injuryen_US
dc.subjectContralateral Testis Injuryen_US
dc.subjectJohnsen's Testicular Biopsy Scoreen_US
dc.subjectInos And Enos Immunohistochemistryen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectBlood-Flowen_US
dc.subjectManganese Complexesen_US
dc.subjectPrepubertal Ratsen_US
dc.subjectEsteren_US
dc.titleEffect of curcumin on ipsilateral and contralateral testes after unilateral testicular torsion in a rat modelen_US
dc.typeArticleen_US

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