Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidgüven, Rabia/B-2261-2019
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidgüven, Rabia/HCI-4600-2022
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorBuldum, Dilek
dc.contributor.authorGuven, Rabia
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGlutamate is the principal excitatory neurotransmitter in the central nervous system. Recent evidence suggests that beta lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Moreover, these antibiotics have been shown to prevent the development of tolerance and dependence to opioids, and reduce visceral and nerve injury-induced neuropathic nociceptive responses. The aim of this study is to observe the effect of a beta lactam antibiotic, ceftriaxone, on mechanical allodynia and mechanical hyperalgesia in diabetic rats. Diabetes was produced with the injection of a single dose of streptozocin (50 mg/kg, i.p.) and this procedure resulted in neuropathic pain behaviors in the hindpaws. Mechanical allodynia was detected with an electronic aesthesiometer, and mechanical hyperalgesia was studied using the method of Randall-Selitto. With its higher doses, ceftriaxone (100, 200 mg/kg, i.p.) reduced both mechanical allodynia and hyperalgesia. Dihydrokainic acid (10 mg/kg, i.p.), a selective GLT-1 transporter inhibitor, reversed the anti-allodynic and anti-hyperalgesic effects of ceftriaxone, at doses that produced no effect on its own. Our results indicate that ceftriaxone exerts an antinociceptive effect in streptozocin-induced diabetic rats and GLT-1 activation by beta lactam antibiotics may be a promising option in the treatment of diabetic neuropathy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.neulet.2010.12.063
dc.identifier.endpage25en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.issue1en_US
dc.identifier.pmid21211547en_US
dc.identifier.scopus2-s2.0-79951516908en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2010.12.063
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22701
dc.identifier.volume491en_US
dc.identifier.wosWOS:000287794400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathyen_US
dc.subjectAllodyniaen_US
dc.subjectHyperalgesiaen_US
dc.subjectCeftriaxoneen_US
dc.subjectDiabetesen_US
dc.subjectBeta-Lactam Antibioticsen_US
dc.subjectNeuropathic Painen_US
dc.subjectTactile Allodyniaen_US
dc.subjectGlutamate Transportersen_US
dc.subjectExpressionen_US
dc.subjectToleranceen_US
dc.subjectMorphineen_US
dc.subjectBrainen_US
dc.subjectAmitriptylineen_US
dc.subjectReceptorsen_US
dc.titleAnti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic ratsen_US
dc.typeArticleen_US

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