Early Effects of Renal Replacement Therapy on Cardiovascular Comorbidity in Children With End-Stage Kidney Disease: Findings From the 4C-T Study

Basit Öğe Kaydı
dc.authoridAzukaitis, Karolis/0000-0001-7953-1338
dc.authoridDeveci, Murat/0000-0001-6246-671X
dc.authoridÖzçakar, Zeynep Birsin/0000-0002-6376-9189
dc.authoridCanpolat, Nur/0000-0002-3420-9756
dc.authoridÇalışkan, Salim/0000-0002-3316-8032
dc.authoridDuzova, Ali/0000-0002-4365-2995
dc.authoridShroff, Rukshana/0000-0001-8501-1072
dc.authorwosidAzukaitis, Karolis/AAQ-8103-2021
dc.authorwosidDeveci, Murat/A-6913-2015
dc.authorwosidÖzçakar, Zeynep Birsin/AAG-1760-2020
dc.authorwosidCanpolat, Nur/V-6807-2017
dc.authorwosidÇalışkan, Salim/ABC-1479-2020
dc.authorwosidDuzova, Ali/AAB-7692-2021
dc.authorwosidShroff, Rukshana/AAG-5383-2019
dc.contributor.authorSchmidt, Bernhard M. W.
dc.contributor.authorSugianto, Rizky Indrameikha
dc.contributor.authorThurn, Daniela
dc.contributor.authorAzukaitis, Karolis
dc.contributor.authorBayazit, Aysun K.
dc.contributor.authorCanpolat, Nur
dc.contributor.authorEroglu, Ayse Guler
dc.date.accessioned2024-06-12T11:19:15Z
dc.date.available2024-06-12T11:19:15Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The early impact of renal transplantation on subclinical cardiovascular measures in pediatric patients has not been widely investigated. This analysis is performed for pediatric patients participating in the prospective cardiovascular comorbidity in children with chronic kidney disease study and focuses on the early effects of renal replacement therapy (RRT) modality on cardiovascular comorbidity in patients receiving a preemptive transplant or started on dialysis. Methods We compared measures indicating subclinical cardiovascular organ damage (aortal pulse wave velocity, carotid intima media thickness, left ventricular mass index) and evaluated cardiovascular risk factors in 166 pediatric patients before and 6 to 18 months after start of RRT (n = 76 transplantation, n = 90 dialysis). Results RRT modality had a significant impact on the change in arterial structure and function: compared to dialysis treatment, transplantation was independently associated with decreases in pulse wave velocity (ss = -0.67; P < 0.001) and intima media thickness (ss = -0.40; P = 0.008). Independent of RRT modality, an increase in pulse wave velocity was associated with an increase in diastolic blood pressure (ss = 0.31; P < 0.001). Increasing intima media thickness was associated with a larger increase in body mass index (ss = 0.26; P = 0.003) and the use of antihypertensive agents after RRT (ss = 0.41; P = 0.007). Changes in left ventricular mass index were associated with changes in systolic blood pressure (ss = 1.47; P = 0.01). Conclusions In comparison with initiating dialysis, preemptive transplantation prevented further deterioration of the subclinical vascular organ damage early after transplantation. Classic cardiovascular risk factors, such as hypertension and obesity are of major importance for the development of cardiovascular organ damage after renal transplantation.en_US
dc.description.sponsorshipGerman Federal Ministry of Education and Research [01EO0802]; European Renal Association - European Dialysis and Transplant Association; KfH Foundation for Preventive Medicine; Roche Organ Transplantation Research Foundation (ROTRF)en_US
dc.description.sponsorshipThis study has been made possible by grants of the German Federal Ministry of Education and Research (reference number: 01EO0802), the European Renal Association - European Dialysis and Transplant Association (www.era-edta.org), the KfH Foundation for Preventive Medicine and the Roche Organ Transplantation Research Foundation (ROTRF).en_US
dc.identifier.doi10.1097/TP.0000000000001948
dc.identifier.endpage492en_US
dc.identifier.issn0041-1337
dc.identifier.issn1534-6080
dc.identifier.issue3en_US
dc.identifier.pmid28926375en_US
dc.identifier.scopus2-s2.0-85042864474en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage484en_US
dc.identifier.urihttps://doi.org/10.1097/TP.0000000000001948
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25135
dc.identifier.volume102en_US
dc.identifier.wosWOS:000426558600033en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofTransplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeft-Ventricular Massen_US
dc.subjectIntima-Media Thicknessen_US
dc.subjectAdolescents Reference Valuesen_US
dc.subjectCarotid-Artery Intimaen_US
dc.subjectPulse-Wave Velocityen_US
dc.subjectMortality Risken_US
dc.subjectPediatric-Patientsen_US
dc.subjectGraft Functionen_US
dc.subjectFollow-Upen_US
dc.subjectHypertrophyen_US
dc.titleEarly Effects of Renal Replacement Therapy on Cardiovascular Comorbidity in Children With End-Stage Kidney Disease: Findings From the 4C-T Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu