Distinguishing Non-Arteritic Ischemic Optic Neuropathy from optic Neuritis with Serum Vitamin B12, Ferritin and Folic Acid Level
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Tarih
2018
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: The aim of this study was to compare the levels of vitamin B12 (Vit B12), folic acid, serum ferritin, serumiron, and total iron binding capacity (TIBC) in patients with optic neuritis (ON) and non-arteritic ischemic optic neuropathy(NAION). It was hoped to determine whether these simple and inexpensive laboratory measurements are indicativefor making a distinction between ON and NAION.Methods: In this retrospective study, the data of patients who were diagnosed with ON and NAION between September2005 and December 2016 were reviewed. In all, 42 patients with NAION, 70 patients with ON, and 76 membersof a control group, a total of 188, were enrolled in the study. All of the participants underwent a full ophthalmologicalexamination and complete physical examination, including a detailed medical history and blood count and evaluation ofthe biochemical parameters, serum ferritin, Vit B12, folic acid, serum iron, and TIBC.Results: The mean serum ferritin level was 236±458.4 ng/mL for the NAION patients, 32.8±34.6 ng/mL for the ONpatients, and 76.1±84.6 ng/mL for the control group. The mean serum Vit B12 level was 478±306.3 pg/mL for the NAIONpatients, 291.7±136.9 pg/mL for the ON patients, and 417.1±163.4 pg/mL for the control group. The mean serum folicacid level was 11.4±6.3 ng/mL for the NAION patients, 6.6±2.7 ng/mL for the ON patients, and 14.5±5.2 ng/mL for thecontrol group.Conclusion: A higher serum ferritin level was significantly associated with NAION, and lower Vit B12 and folic acid wasassociated with ON patients. Serum ferritin, Vit B12, and folic acid measurements could be a useful method for distinguishingbetween NAION and ON before using complicated and invasive methods
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BEYOGLU EYE JOURNAL
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Cilt
3
Sayı
2
