The relationship between 99mTc-HMPAO brain SPECT and the scores of real life rating scale in autistic children

Basit Öğe Kaydı
dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authoridgültekin, aziz/0000-0002-0311-8077
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.authorwosidgültekin, aziz/Q-9820-2018
dc.contributor.authorKaya, M
dc.contributor.authorKarasalihoglu, S
dc.contributor.authorÜstün, F
dc.contributor.authorGültekin, A
dc.contributor.authorÇermik, TF
dc.contributor.authorFazlioglu, Y
dc.contributor.authorTüre, M
dc.date.accessioned2024-06-12T10:52:56Z
dc.date.available2024-06-12T10:52:56Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractChildhood autism is a developmental disability of unknown origin with probable multiple etiologies. The purpose of this study was to compare the changes of regional cerebral blood flow (rCBF) in autistic and non-autistic controls, and to determine the relationship between rCBF on Tc-99m-hexamethylpropylene amine oxime (HMPAO) brain SPECT and the scores of the Ritvo-Freeman Real Life Rating Scale (RLRS), IQ levels, and age of autistic children. Eighteen autistic children (four girls, 14 boys: mean age: 6.13 +/- 1.99 years) and I I non-autistic controls (five girls, six boys, mean age: 6.5 +/- 3.39 years) were examined using Tc-99m-HMPAO brain SPECT. All the children satisfying DSM-IV criteria for autistic disorder were taken into evaluation, and scored by the Ritvo-Freeman RLRS, IQ levels of these children were determined by Goodenough IQ test. Six cortical regions of interest (ROIs; frontal (F), parietal (P), frontotemporal (FT), temporal (T), temporo-occipital (TO), and occipital (0)) were obtained on transaxial slices for count data acquisition. The ratio of average counts in each ROI to whole-slice Counts for the autistic children was correlated with the scores of Ritvo-Freeman RLRS. Hypoperfusion in rCBF in autistic children compared with the control group were identified in bilateral F. FT, T, and TO regions. We found no relationship between rCBF on Tc-99m-HMPAO brain SPECT and the scores of the Ritvo-Freeman RLRS. There was a relationship between bilateral F regions perfusion on Tc-99m-HMPAO brain SPECT and the age of autistic children. There was also a negative correlation between IQ levels and the scores of sensory responses, social relationship to people, and sensory-motor responses. Our results suggest that Tc-99m-HMPAO brain SPECT is helpful to locate the perfusion abnormalities but no correlation is found between rCBF on Tc-99m-HMPAO brain SPECT and the scores of Ritvo-Freeman RLRS. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S0387-7604(02)00006-2
dc.identifier.endpage81en_US
dc.identifier.issn0387-7604
dc.identifier.issue2en_US
dc.identifier.pmid11891096en_US
dc.identifier.scopus2-s2.0-0036005873en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1016/S0387-7604(02)00006-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18888
dc.identifier.volume24en_US
dc.identifier.wosWOS:000174903800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain & Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutismen_US
dc.subjectTc-99m-Hexamethylpropylene Amine Oxime Brain SPECTen_US
dc.subjectRitvo-Freeman Real Life Rating Scaleen_US
dc.subjectCerebral Blood-Flowen_US
dc.subjectChildhood Autismen_US
dc.subjectHmpao Specten_US
dc.subjectAdultsen_US
dc.subjectRecognitionen_US
dc.subjectIqen_US
dc.titleThe relationship between 99mTc-HMPAO brain SPECT and the scores of real life rating scale in autistic childrenen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu