The Development of Acute Kidney Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

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dc.contributor.authorErkut, Nergiz
dc.contributor.authorErmantaş, Nilay
dc.contributor.authorÖzbaş, Hasan Mücahit
dc.contributor.authorYüzbaşıoğlu, Şule
dc.contributor.authorÇankaya, Sertaç
dc.contributor.authorSönmez, Mehmet
dc.date.accessioned2024-06-12T10:13:30Z
dc.date.available2024-06-12T10:13:30Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractINTRODUCTION: Acute kidney disease is an important complication of allogeneic hematopoietic stem cell transplantation. The aim of this retrospective study was to identify major risk factors for acute kidney disease in hematopoietic stem cell transplantation and its effect on patients survival. METHODS: This study was a retrospective review of 77 patients with allogeneic hematopoietic stem cell transplantation at our department from January 2007 to October 2015. RESULTS: Acute kidney disease developed in 25 of 77 patients (32.5%). The median time to development of acute kidney disease after transplantation was 30 days. Univariate analysis showed that baseline serum gammaglutamyl transpeptidase level, amphotericin B use and cyclosporine level were associated with the development of acute kidney disease. Logistic regression multivariate analysis showed that amphotericin B use, cytomegalovirus reactivation, conditioning regimen and cyclosporine level were an independent risk factor for acute kidney disease. Mortality and non-relapse mortality rates were higher in patients with acute kidney disease than in those without acute kidney disease. In Kaplan-Meier analysis, median survival was 18.4 months in patients without acute kidney disease and 12.2 months in patients with acute kidney disease. DISCUSSION and CONCLUSION: Acute kidney disease has a poor prognosis in hematopoietic stem cell transplantation and conditioning regimen, cytomegalovirus reactivation, amphotericin B use and particularly cyclosporine level are independent risk factors in the development of acute kidney disease in hematopoietic stem cell transplantation recipients.en_US
dc.identifier.endpage144en_US
dc.identifier.issn0304-596X
dc.identifier.issn2148-7669
dc.identifier.issue2en_US
dc.identifier.startpage136en_US
dc.identifier.trdizinid293939en_US]
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/293939
dc.identifier.urihttps://hdl.handle.net/20.500.14551/14035
dc.identifier.volume51en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofACTA ONCOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Development of Acute Kidney Disease Following Allogeneic Hematopoietic Stem Cell Transplantationen_US
dc.typeArticleen_US

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