The relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; correlations with clinicopathologic parameters

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dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOzyilmaz, Filiz/A-4865-2016
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorCan, Nuray
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorUsta, Ufuk
dc.contributor.authorSut, Necdet
dc.contributor.authorTastekin, Ebru
dc.contributor.authorAltaner, Semsi
dc.date.accessioned2024-06-12T11:02:31Z
dc.date.available2024-06-12T11:02:31Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose Several studies performed on pancreatic-duodenal homeobox 1 (PDX1) have demonstrated a loss of expression and negative tumor modulator effect in gastric carcinoma. Relations between PDX1 and gastric metaplasia, differentiated type of gastric carcinoma, and the early stage of the disease have been exhibited in previous reports. The aim of this study was to examine expressions of PDX1, caudal type homeobox 2 (CDX2) and mucin (MUC) profiles to address the role of PDX1 in gastric carcinogenesis and its relationship with CDX2. Methods Seventy gastrectomy specimens were analyzed immunohistochemically for PDX1, CDX2, MUC2, MUC5AC, and MUC6 expressions. The sum of cytoplasmic and nuclear PDX1 immunostaining and PDX1 positivity were assessed. All of the antibodies were examined for a correlation with tumor type, clinicopathologic parameters, and metaplasias. The relation of Ki-67 proliferation index with the expression profiles was also investigated. Results Neither PDX1 (66/70) nor CDX2 (37/70) and the mucin profiles (MUC2: 11/70, MUC5AC: 48/70, MUC6: 41/70) showed a significant difference between differentiated and undifferentiated types of gastric carcinoma and clinicopathologic parameters. The PDX1 expression frequency was 94.3%, with an average PDX1 score of 8.8 +/- 4.2. PDX1 and CDX2 expression showed a significant difference (P = 0.026 and P = 0.002, respectively) among the phenotypic classification of gastric carcinomas. All of the gastric and intestinal mixed-phenotype gastric carcinomas (GI-type) showed both PDX1 and CDX2 immunopositivity. Except for the relation of PDX1 score with MUC6 expression, no significant difference was detected between PDX1 and CDX2, MUC2, and MUC5AC expressions. A relationship between CDX2 and MUC2 and also between MUC5AC and MUC6 was found statistically. The Ki-67 proliferation index revealed a significant positive correlation with PDX1, CDX2, and MUC2 positivity. Conclusions PDX1 expression revealed a higher positivity in gastric carcinomas than the previous studies and showed no relation with tumor type, clinicopathologic parameters, CDX2 expression, or mucin profiles. However, a significant relation of PDX1 and CDX2 expressions among phenotypic classification of gastric carcinomas reveals an idea about similar functions for PDX1 and CDX2 in the evolution of gastric carcinoma.en_US
dc.identifier.doi10.1007/s00432-011-1044-7
dc.identifier.endpage1762en_US
dc.identifier.issn0171-5216
dc.identifier.issn1432-1335
dc.identifier.issue12en_US
dc.identifier.pmid21909647en_US
dc.identifier.scopus2-s2.0-82955233664en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1749en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-011-1044-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21295
dc.identifier.volume137en_US
dc.identifier.wosWOS:000300344100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Cancer Research And Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric Carcinomaen_US
dc.subjectCarcinogenesisen_US
dc.subjectPDX1en_US
dc.subjectCDX2en_US
dc.subjectMucinsen_US
dc.subjectPolypeptide-Expressing Metaplasiaen_US
dc.subjectPancreatic Duodenal Homeobox-1en_US
dc.subjectHelicobacter-Pylori Infectionen_US
dc.subjectHomeodomain Protein Cdx2en_US
dc.subjectIntestinal Metaplasiaen_US
dc.subjectPrognostic-Significanceen_US
dc.subjectTrefoil Peptidesen_US
dc.subjectHox Genesen_US
dc.subjectCanceren_US
dc.subjectDifferentiationen_US
dc.titleThe relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; correlations with clinicopathologic parametersen_US
dc.typeArticleen_US

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