Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish population

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dc.authoridSayan, Murat/0000-0002-4374-7193
dc.authoridArslan Ateş, Esra/0000-0001-5552-8134
dc.authoridErgoren, Mahmut Cerkez/0000-0001-9593-9325
dc.authoridDundar, Munis/0000-0003-0969-4611
dc.authoridATA, PINAR/0000-0002-6688-2347
dc.authoridCanbek, Sezin/0000-0001-9516-0047
dc.authoridSayan, Murat/0000-0002-4374-7193
dc.authorwosidSayan, Murat/GZM-2963-2022
dc.authorwosidArslan Ateş, Esra/AAM-1394-2021
dc.authorwosidalemdar, adem/HIZ-7332-2022
dc.authorwosidErgoren, Mahmut Cerkez/GQP-2509-2022
dc.authorwosidDundar, Munis/B-3150-2011
dc.authorwosidATA, PINAR/AAC-9967-2020
dc.authorwosidCanbek, Sezin/JUF-1080-2023
dc.contributor.authorDuman, Nilgun
dc.contributor.authorTuncel, Gulten
dc.contributor.authorBisgin, Atil
dc.contributor.authorBozdogan, Sevcan Tug
dc.contributor.authorSag, Sebnem Ozemri
dc.contributor.authorGul, Seref
dc.contributor.authorKiraz, Aslihan
dc.date.accessioned2024-06-12T10:50:19Z
dc.date.available2024-06-12T10:50:19Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHeterogeneity in symptoms associated with COVID-19 in infected patients remains unclear. ACE2 and TMPRSS2 gene variants are considered possible risk factors for COVID-19. In this study, a retrospective comparative genome analysis of the ACE2 and TMPRSS2 variants from 946 whole-exome sequencing data was conducted. Allele frequencies of all variants were calculated and filtered to remove variants with allele frequencies lower than 0.003 and to prioritize functional coding variants. The majority of detected variants were intronic, only two ACE2 and three TMPRSS2 nonsynonymous variants were detected in the analyzed cohort. The main ACE2 variants that putatively have a protective or susceptibility effect on SARS-CoV-2 have not yet been determined in the Turkish population. The Turkish genetic makeup likely lacks any ACE2 variant that increases susceptibility to SARS-CoV-2 infection. TMPRSS2 rs75603675 and rs12329760 variants that were previously defined as common variants that have different allele frequencies among populations and may have a role in SARS-CoV-2 attachment to host cells were determined in the population. Overall, these data will contribute to the formation of a national variation database and may also contribute to further studies of ACE2 and TMPRSS2 in the Turkish population and differences in SARS-CoV-2 infection among other populations.en_US
dc.identifier.doi10.1002/jmv.27976
dc.identifier.endpage5243en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue11en_US
dc.identifier.pmid35811452en_US
dc.identifier.scopus2-s2.0-85134590279en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5225en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.27976
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17963
dc.identifier.volume94en_US
dc.identifier.wosWOS:000829989200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectACE2en_US
dc.subjectCOVID-19en_US
dc.subjectSARS-Cov-2en_US
dc.subjectTMPRSS2en_US
dc.subjectVarianten_US
dc.subjectReceptoren_US
dc.subjectCoronavirusen_US
dc.titleAnalysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish populationen_US
dc.typeArticleen_US

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