Investigation of the relationship between MMP-1 (-1607 1G/2G), MMP-3 (-1171 5A/6A) gene variations and development of bladder cancer

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dc.authoridÇevik, Gökhan/0000-0001-5221-5132
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidÇevik, Gökhan/GZA-3993-2022
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorCevik, Gokhan
dc.date.accessioned2024-06-12T10:56:25Z
dc.date.available2024-06-12T10:56:25Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Chronic inflammation is an important risk factor in the development of bladder cancer. It may stimulate growth and metastasis of cancer cells. The inflammatory process includes MMP activities and expression. MMP activation can be stimulated by various inflammatory cells. Pathological processes such as bladder cancer may occur due to imbalance in MMP activities. In our study, we aimed to determine the relationship between MMP-1, MMP-3 gene variations associated with chronic inflammation and the bladder cancer development. Methods Our study was carried out with 89 bladder cancer patients and 78 healthy controls. PCR-RFLP methods were applied to determine MMP-1 and MMP-3 gene variations genotype distributions. Results 1G/1G homozygous and 1G/2G heterozygous genotypes of MMP-1 gene variation were determined more in patients than controls. The 5A/5A homozygous and 5A/6A heterozygous genotypes of the MMP-3 gene variation were detected more in patients than controls. The significant difference was detected in terms of genotype distributions of MMP-1 and MMP-3 gene variations between these groups (p < 0.05). In addition to, the most common haplotype in the patient group were detected as 1G/2G-5A/6A (20.22%). Conclusion In this study, MMP-1 and MMP-3 gene variations were determined as possible genetic risk factors for bladder cancer development in the Thrace population.en_US
dc.identifier.doi10.1007/s11033-021-06775-2
dc.identifier.endpage7695en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue12en_US
dc.identifier.pmid34693500en_US
dc.identifier.scopus2-s2.0-85117749438en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7689en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06775-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19786
dc.identifier.volume48en_US
dc.identifier.wosWOS:000710327600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Inflammationen_US
dc.subjectBladder Canceren_US
dc.subjectMMP-1 Gene Variationen_US
dc.subjectMMP-3 Gene Variationen_US
dc.subjectPCR-RFLPen_US
dc.subject3 Polymorphismsen_US
dc.subjectAssociationen_US
dc.subjectRisken_US
dc.titleInvestigation of the relationship between MMP-1 (-1607 1G/2G), MMP-3 (-1171 5A/6A) gene variations and development of bladder canceren_US
dc.typeArticleen_US

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