Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia

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dc.authoridBAHTİYAR, NURTEN/0000-0003-2420-8415
dc.authoridCinemre, Fatma Behice/0000-0002-1972-1575
dc.authoridAydemir, Birsen/0000-0003-1406-864X;
dc.authorwosidYILDIZ, Mustafa/P-9934-2015
dc.authorwosidSimsek, Arife/C-7348-2019
dc.authorwosidBAHTİYAR, NURTEN/IZP-9481-2023
dc.authorwosidYILDIZ, Mustafa/B-7520-2016
dc.authorwosidCinemre, Fatma Behice/JHS-8430-2023
dc.authorwosidTüten, Abdullah/E-2856-2019
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorErdogan, Elif
dc.contributor.authorDilaveroglu, Nilgun
dc.contributor.authorTuten, Abdullah
dc.contributor.authorKaya, Baris
dc.contributor.authorYilmaz, Nevin
dc.date.accessioned2024-06-12T11:12:48Z
dc.date.available2024-06-12T11:12:48Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To investigate the role of selenoprotein W1 (SEPW1) single nucleotide polymorphism (SNP) in etiopathogenesis of pre-eclampsia (PE) and its association with maternal selenoprotein W (SelW) and selenium levels. Materials and methods: In this study, 98 pregnant women who were diagnosed with PE and 100 healthy pregnant controls were investigated. To identify the polymorphism of the SEPW1 gene (rs3786777), allele-specific polymerase chain reaction (ASPCR) analysis was used. Serum selenium levels and plasma SelW levels were measured by graphite-furnace atomic absorption spectrophotometry and by ELISA, respectively. Results: Maternal selenium levels (mu g/L) were 92.56 +/- 6.10 and 86.26 +/- 6.33 in pregnant women with and without PE, respectively (p > 0.05). On the other hand, SelW levels (ng/mL) were significantly lower in PE (72.08 +/- 8.10) compared to controls (89.29 +/- 6.99) (p < 0.01). The frequencies of the CC, CA, and AA genotypes were found to be 26%, 61%, and 13% in pregnant women with PE and 28%, 55%, and 17% in healthy pregnant controls. The distribution of the SEPW1 genotypes and alleles did not differ significantly among subjects with and without PE. In PE patients, SelW levels were lower in CC and CA genotypes compared to controls (p < 0.05 and p < 0.001). Conclusion: SEPW1 gene polymorphism did not seem to affect risk of PE in our population. However, SelW levels were low in some genotypes of the gene, suggesting that SelW might have played a role in the etiopathogenesis of PE.en_US
dc.identifier.doi10.5414/TEX01542
dc.identifier.endpage67en_US
dc.identifier.issn0946-2104
dc.identifier.issue2en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.5414/TEX01542
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23293
dc.identifier.volume36en_US
dc.identifier.wosWOS:000461900500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofTrace Elements And Electrolytesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPre-Eclampsiaen_US
dc.subjectSEPW1 Gene Polymorphismen_US
dc.subjectSeleniumen_US
dc.subjectSelenoprotein-Wen_US
dc.subjectCell-Cycle Progressionen_US
dc.subjectAntiangiogenic Factorsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectTrace-Elementsen_US
dc.subjectDiseaseen_US
dc.subjectSerumen_US
dc.subjectExpressionen_US
dc.subjectDepletionen_US
dc.subjectCanceren_US
dc.subjectSepw1en_US
dc.titleAssociation of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsiaen_US
dc.typeArticleen_US

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