The comparison of electron microscopy and scintigraphy in determining the protective effect of dimethylsulphoxide (DMSO) on ischemia/reperfusion injury through pringle maneuver

Basit Öğe Kaydı
dc.contributor.authorHatipoglu, AR
dc.contributor.authorTemiz, E
dc.contributor.authorYüksel, M
dc.contributor.authorHoscoskun, Z
dc.contributor.authorCoskun, I
dc.contributor.authorHüseyinova, G
dc.date.accessioned2024-06-12T11:03:09Z
dc.date.available2024-06-12T11:03:09Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/Aims: We investigated the role of the electron microscopy and hepatobiliary scintigraphy in determining the effect of DMSO (dimethysulphoxide) and ischemia/reperfusion injury in the liver after the Pringle maneuver. Methodology: Twenty-four rabbits were divided into the following groups; A: Control group, B: Pringle, C: 10mg/kg DMSO, D: 1g/kg DMSO + Pringle. Group A was considered as a control group and only laparotomy was applied. Group B was exposed to Pringle maneuver only. Group C:was given 10mg/kg of DMSO via the vena cava inferior. Group D was given 1g/kg of DMSO- A clamp was fastened for the groups of B, C and D in the 30th minute of the Pringle maneuver and a biopsy was applied five minutes later. Fifteen minutes later a dynamic hepatobiliary scintigraphy was applied. From dynamic images, liver peak time and activity half time of the liver were obtained. Results: It was found that liver peak time and liver activity half time values of the group B, C and D were significantly longer than group A. Liver peak time and liver activity half time values of group B was not different from group C. However, some values of group D were found to be significantly shorter than groups B and C. In the electron microscopy examination, only in group B were some specific degenerative changes observed in the sinusoids. We observed less irreversible changes in group C than in group B. Oh the other hand, the least irreversible changes were in group D. Conclusions: As a conclusion, while electron microscopy is regarded as the gold standard, hepatobiliary scintigraphy may be thought of as an easily applicable: method in determining the ischemic reperfusion injury in the clinical comparison of the protective agents.en_US
dc.identifier.endpage802en_US
dc.identifier.issn0172-6390
dc.identifier.issue39en_US
dc.identifier.scopus2-s2.0-0034930777en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage798en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21553
dc.identifier.volume48en_US
dc.identifier.wosWOS:000169631600045en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatobiliary Scintigraphyen_US
dc.subjectDMSOen_US
dc.subjectElectron Microscopyen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectFree-Radical Scavengersen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectDimethyl-Sulfoxideen_US
dc.subjectLiver Ischemiaen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxygen Radicalsen_US
dc.subjectRat-Liveren_US
dc.subjectMetabolismen_US
dc.subjectDimethylsulfoxideen_US
dc.titleThe comparison of electron microscopy and scintigraphy in determining the protective effect of dimethylsulphoxide (DMSO) on ischemia/reperfusion injury through pringle maneuveren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu