Protective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Rats

Basit Öğe Kaydı
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.authoridKARACA, Turan/0000-0002-2500-7781;
dc.authorwosidHanci, Volkan/Q-1573-2019
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidKara, Selcuk/C-8315-2015
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.contributor.authorKara, Selcuk
dc.contributor.authorGencer, Baran
dc.contributor.authorKaraca, Turan
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorArikan, Sedat
dc.contributor.authorErsan, Ismail
dc.contributor.authorKaraboga, Ihsan
dc.date.accessioned2024-06-12T11:18:57Z
dc.date.available2024-06-12T11:18:57Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose. Hesperetin and naringenin are naturally common flavonoids reported to have antioxidative effects. This study was performed to investigate whether either hesperetin or naringenin has a protective effect against apoptosis on retinal ischemia/reperfusion (I/R) injury. Methods. Retinal I/R was induced by increasing the intraocular pressure to 150 mm Hg for 60 minutes. Thirty-three male Wistar albino rats were randomised into 5 groups named control, I/R + sham, I/R + solvent (DMSO), I/R + hesperetin, and I/R + naringenin. Animals were given either hesperetin, naringenin, or the solvent intraperitoneally immediately following reperfusion. Thickness of retinal layers and retinal cell apoptosis were detected by histological analysis, tunel assay, and immunohistochemistry assay. Results. Hesperetin and naringenin attenuated the I/R-induced apoptosis of retinal cells in the inner and outer nuclear cells of the rat retina. Retinal layer thickness of the naringenin treatment group was significantly thicker than that of the hesperetin, sham, and solvent groups (P < 0.05). Conclusions. Hesperetin and naringenin can prevent harmful effects induced by I/R injury in the rat retina by inhibiting apoptosis of retinal cells, which suggests that those flavanones have a therapeutic potential for the protection of ocular ischemic diseases.en_US
dc.identifier.doi10.1155/2014/797824
dc.identifier.issn1537-744X
dc.identifier.pmid24616645en_US
dc.identifier.scopus2-s2.0-84898803130en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2014/797824
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25012
dc.identifier.wosWOS:000330893000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofScientific World Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunction Recoveryen_US
dc.subjectCitrus Flavononeen_US
dc.subjectGanglion-Cellsen_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.subjectAntioxidanten_US
dc.subjectFlavanoneen_US
dc.subjectSurvivalen_US
dc.subjectEfficacyen_US
dc.subjectInsulten_US
dc.titleProtective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu