The protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in rats

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.authorwosidToman, Huseyin/GSM-7134-2022
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.authorwosidToman, Hüseyin/AAD-1979-2019
dc.authorwosidKara, Selcuk/C-8315-2015
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidHanci, Volkan/Q-1573-2019
dc.contributor.authorGencer, Baran
dc.contributor.authorKaraca, Turan
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorKara, Selcuk
dc.contributor.authorArikan, Sedat
dc.contributor.authorToman, Huseyin
dc.contributor.authorKaraboga, Ihsan
dc.date.accessioned2024-06-12T10:52:27Z
dc.date.available2024-06-12T10:52:27Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Dexmedetomidine is an alpha 2 adrenoceptor agonist and can be used for postoperative sedation, analgesia and anesthesia-sparing properties. Furthermore, the neuroprotective effects against ischemia/reperfusion (I/R) injury in the central nervous system have been shown in experimental studies. This study aimed to investigate the protective effects of dexmedetomidine against apoptosis in retinal I/R injury in the rat. Materials and methods: Retinal I/R injury was induced by transient elevation of intraocular pressure. Eighteen animals were divided into three groups (n = 6): sham, I/R and treatment. The I/R injury and protective effects of the dexmedetomidine were evaluated by retinal thickness determined by histological sections, terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL) and immunohistochemistry of caspases 3. Results: A decrease in the retinal thickness and an increase in the apoptotic cells were found to be statistically significant in I/R and treatment groups when compared with the control group. However, in comparison with the I/R group we realized that the administration of dexmedetomidine reduced the thinning of retinal thickness and also decreased the number of caspases 3 and TUNEL-positive cells. Conclusion: Dexmedetomidine is protective against apoptosis in retinal I/R injury in rats.en_US
dc.identifier.doi10.3109/15569527.2013.857677
dc.identifier.endpage288en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4en_US
dc.identifier.pmid24517497en_US
dc.identifier.scopus2-s2.0-84912101780en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2013.857677
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18690
dc.identifier.volume33en_US
dc.identifier.wosWOS:000345498400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous And Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectDexmedetomidineen_US
dc.subjectRetinal Ischemia/Reperfusion Injuryen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectCerebral-Ischemiaen_US
dc.subjectGlutamate Releaseen_US
dc.subjectAgonisten_US
dc.subjectModelen_US
dc.subjectDamageen_US
dc.subjectNeurotoxicityen_US
dc.subjectDegenerationen_US
dc.subjectPathogenesisen_US
dc.subjectExpressionen_US
dc.titleThe protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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