Genotoxic effects of Triasulfuron in cultured human lymphocytes

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dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.contributor.authorMuranli, Fulya D. Gokalp
dc.contributor.authorKaymak, Fisun
dc.date.accessioned2024-06-12T11:16:41Z
dc.date.available2024-06-12T11:16:41Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the genotoxic effects of Triasulfuron, which is used as a sulfonylurea herbicide, on human peripheral blood lymphocytes in vitro by using chromosome aberration, sister chromatid exchange and micronucleus tests. Lymphocytes were treated with five different concentrations of Triasulfuron (5, 10, 50, 100, 200 mu g/ml) for 24 and 48 hours. The herbicide did not induce a significant increase in the CA frequency at any of the concentrations, but increased significantly MN formation at the highest concentration (200 mu g/ml) and SCE at all of the concentrations for 24 and 48 hours treatment periods when compared with the negative control. Also this herbicide reduced the mitotic index, cytokinesis-block proliferation index and proliferation index values significantly. The results indicated that Triasulfuron is not clastogenic since it did not induce CA frequency, but it has a probable genotoxic effect and cytotoxic potential due to induction in SCE frequency and reduction in both mitotic and replication indexes in human peripheral lymphocytes in vitro.en_US
dc.description.sponsorshipTrakya University [TUFEF 673/2006]en_US
dc.description.sponsorshipThe authors thank the Trakya University for the financial support under grant No. TUFEF 673/2006. This study is part of a PhD thesis.en_US
dc.identifier.endpage1013en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue8Aen_US
dc.identifier.scopus2-s2.0-52949150796en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1007en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24400
dc.identifier.volume17en_US
dc.identifier.wosWOS:000259838000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTriasulfuronen_US
dc.subjectToxicologyen_US
dc.subjectHuman Peripheral Lymphocytesen_US
dc.subjectChromosome Aberrationsen_US
dc.subjectSister Chromatid Exchangesen_US
dc.subjectMicronucleien_US
dc.subjectSister-Chromatid Exchangesen_US
dc.subjectMouse Bone-Marrowen_US
dc.subjectIn-Vitroen_US
dc.subjectChromosome-Aberrationsen_US
dc.subjectGenetic Toxicologyen_US
dc.subjectInductionen_US
dc.subjectCellsen_US
dc.subjectVivoen_US
dc.subjectInsecticideen_US
dc.subjectMicronucleien_US
dc.titleGenotoxic effects of Triasulfuron in cultured human lymphocytesen_US
dc.typeArticleen_US

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