Relationship Between Endothelial Functions and Acetylsalicylic Acid Resistance in Newly Diagnosed Hypertensive Patients

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dc.authoridURAL, DILEK/0000-0003-0224-1433
dc.authorwosidUral, Dilek/HMV-0020-2023
dc.authorwosidCelikyurt, Umut/AAG-2320-2021
dc.contributor.authorSahin, Tayfun
dc.contributor.authorCelikyurt, Umut
dc.contributor.authorGeyik, Bilal
dc.contributor.authorOner, Gokhan
dc.contributor.authorKilic, Teoman
dc.contributor.authorBildirici, Ulas
dc.contributor.authorKozdag, Guliz
dc.date.accessioned2024-06-12T11:18:40Z
dc.date.available2024-06-12T11:18:40Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: We aimed to investigate the effects and dose dependency of aspirin on endothelial functions and prevalence of aspirin resistance in newly diagnosed hypertensive patients without previous drug therapy and development of cardiac complications. Hypothesis: Acetylsalicyclic acid improves endothelial function. Methods: Fifty-eight hypertensive patients and 61 healthy subjects in the control group were included in the study. Endothelial functions of the patient and control groups were evaluated with brachial artery examination. Patient and control groups were divided into 2 groups. A total of 100 mg and 300 mg of aspirin were given to the separate groups for 1 week. After 1 week, endothelial functions were reevaluated and aspirin resistance examined with a platelet function analyzer (PFA-100; Dade Behring, Marbourg, Germany). Results: Baseline flow-mediated dilatation (FMD) change percent in hypertensive patients was 9.8%, and it was significantly lower than in the control group (12%) (P < 0.001). Frequency of acetylsalicylic acid (ASA) resistance was 20% and 26% in control and hypertensive patient groups, respectively (P = not significant). ASA resistance was 28% and 24% in 100 mg and 300 mg in hypertensive patients, respectively (P = not significant). FMD change percent increased both in the control and hypertensive groups after ASA treatment from 12.4% to 13.3% and 9.8 % to 11.9 %, respectively. FMD percentage change was significantly increased in hypertensive patients irrespective of ASA resistance (P = 0.02, for ASA resistance [+]; P < 0.012, for ASA resistance [-]). Conclusions: Endothelial functions were impaired more in hypertensive patients compared to the control group. Endothelial functions were improved with all ASA doses in hypertensive patients irrespective of ASA resistance. The authors have no funding, financial relationships, or conflicts of interest to disclose.en_US
dc.identifier.doi10.1002/clc.22042
dc.identifier.endpage763en_US
dc.identifier.issn0160-9289
dc.identifier.issn1932-8737
dc.identifier.issue12en_US
dc.identifier.pmid22847393en_US
dc.identifier.scopus2-s2.0-84870918391en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage755en_US
dc.identifier.urihttps://doi.org/10.1002/clc.22042
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24903
dc.identifier.volume35en_US
dc.identifier.wosWOS:000312248700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectAspirin Resistanceen_US
dc.subjectNitric-Oxideen_US
dc.subjectOxidative Stressen_US
dc.subjectRisk-Factorsen_US
dc.subjectDysfunctionen_US
dc.subjectVasodilationen_US
dc.subjectInflammationen_US
dc.subjectPrevalenceen_US
dc.subjectPreventionen_US
dc.titleRelationship Between Endothelial Functions and Acetylsalicylic Acid Resistance in Newly Diagnosed Hypertensive Patientsen_US
dc.typeArticleen_US

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