Factors related to recurrence after pathological complete response to postoperative chemotherapy in patients with epithelial ovarian cancer

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dc.authoridEralp, Yesim/0000-0001-9603-4755
dc.authorwosidSaip, pınar/AAT-1500-2020
dc.authorwosidTopuz, Samet/AAY-8615-2020
dc.authorwosidEralp, Yesim/AAD-7194-2020
dc.contributor.authorKaragol, Hakan
dc.contributor.authorSaip, Pinar
dc.contributor.authorEralp, Yesim
dc.contributor.authorTopuz, Samet
dc.contributor.authorBerkman, Sinan
dc.contributor.authorIlhan, Ridvan
dc.contributor.authorTopuz, Erkan
dc.date.accessioned2024-06-12T11:11:50Z
dc.date.available2024-06-12T11:11:50Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims and background. It has been appreciated for some time that the lack of detection of ovarian cancer at clinical and pathological (second-look laparotomy) evaluation is not synonymous with cure. The goal of this study was to define clinical risk factors for recurrence after complete pathological response to postoperative chemotherapy in patients with epithelial ovarian cancer. Methods. Fifty-seven patients who met the inclusion criteria of our study were evaluated. The characteristics (age, menopausal status, histological subtype, tumor grade, presence of ascites at diagnosis, type of omentectomy, FIGO stage, and residual tumor volume after primary surgery) of patients with and those Without tumor recurrence were compared. Results. The median follow-up was 52 months (range, 15-142 months). The overall survival rates of the patients were 100%, 96%, and 87% at 1, 3 and 5 years, respectively At the time of the study analysis, 21 of 57 (37%) patients had recurrent disease. The median time to recurrence was 16 months. Recurrences were most frequent in the pelvis and abdominal cavity (38%). Age, menopausal status, stage at diagnosis, and residual tumor volume after initial surgery were significantly related to the risk of recurrence in univariate analysis (P = 0.039, 0.038, 0.004, and 0.000, respectively). Residual tumor volume after initial surgery-was found to be the only significant independent prognostic factor (P = 0.049, HR: 0.16, 95% CI: 0.02-0.99). Conclusion. We believe it is necessary to conduct randomized studies on this issue because insight into predictors of recurrence after pathological complete response to postoperative chemotherapy could be used to select patients for trials of consolidation therapy.en_US
dc.identifier.endpage211en_US
dc.identifier.issn0300-8916
dc.identifier.issue2en_US
dc.identifier.pmid19579867en_US
dc.identifier.scopus2-s2.0-67649124921en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22955
dc.identifier.volume95en_US
dc.identifier.wosWOS:000266226200012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPensiero Scientifico Editoren_US
dc.relation.ispartofTumorien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian Canceren_US
dc.subjectNegative Second-Look Laparotomyen_US
dc.subjectRecurrenceen_US
dc.subjectNegative 2nd-Look Laparotomyen_US
dc.subjectGynecologic-Oncology-Groupen_US
dc.subjectIntraperitoneal Cisplatinen_US
dc.subjectPhase-Iiien_US
dc.subjectSurvivalen_US
dc.subjectPaclitaxelen_US
dc.subjectPlatinumen_US
dc.subjectCarcinomaen_US
dc.subjectSurgeryen_US
dc.subjectTrialen_US
dc.titleFactors related to recurrence after pathological complete response to postoperative chemotherapy in patients with epithelial ovarian canceren_US
dc.typeArticleen_US

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