Efficacy of Sunitinib, Sunitinib-Hesperetin, and Sunitinib-Doxycycline Combinations on Experimentally-Induced Corneal Neovascularization

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorEkim, Yeliz
dc.contributor.authorKara, Selcuk
dc.contributor.authorGencer, Baran
dc.contributor.authorKaraca, Turan
dc.date.accessioned2024-06-12T10:58:34Z
dc.date.available2024-06-12T10:58:34Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To investigate the preventive effects of topical sunitinib, sunitinib-hesperetin and sunitinib-doxycycline combinations on corneal neovascularization (CNV), apoptosis and fibrosis in a corneal alkali burn model.Materials and Methods: The corneas of 32 Wistar albino rats were cauterized with silver nitrate to induce CNV. Four groups were created receiving artificial tears (sham), sunitinib (0.5 mg/ml), sunitinib-hesperetin (0.5 mg/ml-0.2 mg/ml), and sunitinib-doxycycline (0.5 mg/ml-20 mg/ml) treatments. Corneal photographs were taken on days 0, 7 and 15. Photographs of the cornea were digitally analyzed to measure the size of the neovascularization area in comparison to the total corneal surface area. On the 15th day, the animals were euthanized, and the eyes were enucleated for immunohistochemical staining to investigate neovascularization, apoptosis, and fibrosis.Results: CNV areas on the 7th day in the sunitinib (4.8%0.07%) and sunitinib-hesperetin (1.1%+/- 0.03%) groups were smaller than those in the sham group (33.9%+/- 0.12%) (p=0.001 and, p <0.001 respectively). On the 15th day, the CNV area in the sunitinib-hesperetin (20.8%+/- 0.37%) group was significantly smaller than that of the sham group (74.6%+/- 0.32%) (p=0.039). The combination groups had lower levels of VEGF, TUNEL and -SMA positivity than the sunitinib monotherapy group. TUNEL positivity was lowest in the sunitinib-hesperetin and sunitinib-doxycycline groups, and -SMA positivity was lowest in the sunitinib-hesperetin group.Conclusion: Topical sunitinib-hesperetin was more effective than sunitinib alone and the sunitinib-doxycycline combination in the treatment of CNV. The combination of sunitinib and hesperetin seems to be a promising treatment for preventing corneal fibrosis and apoptosis.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [115S032]en_US
dc.description.sponsorshipThis study was funded from The Scientific and Technological Research Council of Turkey (TUBITAK) (Grant No: 115S032).en_US
dc.identifier.doi10.1080/02713683.2019.1584320
dc.identifier.endpage598en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue6en_US
dc.identifier.pmid30803276en_US
dc.identifier.scopus2-s2.0-85062718195en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage590en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2019.1584320
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20102
dc.identifier.volume44en_US
dc.identifier.wosWOS:000471943300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneal Neovascularizationen_US
dc.subjectSunitiniben_US
dc.subjectHesperetinen_US
dc.subjectDoxycyclineen_US
dc.subjectFibrosisen_US
dc.subjectApoptosisen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectFactor Therapyen_US
dc.subjectEye Dropsen_US
dc.subjectIn-Vitroen_US
dc.subjectBevacizumaben_US
dc.subjectInhibitionen_US
dc.subjectSubconjunctivalen_US
dc.subjectExpressionen_US
dc.subjectFibrosisen_US
dc.subjectVegfen_US
dc.titleEfficacy of Sunitinib, Sunitinib-Hesperetin, and Sunitinib-Doxycycline Combinations on Experimentally-Induced Corneal Neovascularizationen_US
dc.typeArticleen_US

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