Hormone profiles and clinical outcome after laparoscopic ovarian drilling in women with polycystic ovary syndrome

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dc.contributor.authorKucuk, M
dc.contributor.authorKilic-Okman, T
dc.date.accessioned2024-06-12T11:07:27Z
dc.date.available2024-06-12T11:07:27Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The aim of our study was to evaluate the results of laparoscopic treatment in women with polycystic ovary syndrome, and to compare their response with ovulation, homocysteine levels, hormone profiles and clinical outcome before and after drilling. Material/Methods: We studied twenty-two nulliparous oligomenorrheic women with polycystic ovaries, complaining of infertility refractory to clomiphene-citrate treatment and subsequently underwent laparoscopic ovarian drilling (LOD) with a needle electrocautery. Endocrine assays, lipoproteins, homocysteine determinations and ultrasound evaluation were performed in all women before and after the procedure. Ovulatory and pregnancy rates and clinical outcome were assessed. Results: After the procedure, serum T, LH, homocysteine levels and LH-FSH ratio were significantly lower than at baseline (0.93+/-0.15 vs 0.67+/-0.11 ng/ml, p<0.001; 12.72+/-1.13 vs 7.36+/-0.57 mIU/ml, p<0.001; 9.77+/-1.06 vs 7.13+/-0.99 mumol/L, p<0.001; 2.16+/-0.22 vs 1.29+/-0.13, p<0.001, respectively). In addition, SHBG levels were higher than at baseline (370.7+/-19.08 vs 404.7+/-16.71 nmol/L, p<0.001) No reduction in high-density lipoprotein cholesterol was observed after the procedure. Similarly, no differences were observed between treating women with LOD and their baseline measurements in E-2, FSH, DHEAS, and PRL concentrations (p=0.255, p=0.140, p=0.250, p=0.137, respectively). Ovulation occurred spontaneously in 77% of women after the procedure. The chance of conception at 12 months after surgery was 54%. Conclusions: LOD appears to be a promising alternative treatment for patients with PCOS. Our results show that LOD may cause a significant reduction in serum concentration of homocysteine in patients with PCOS.en_US
dc.identifier.endpageCR34en_US
dc.identifier.issn1643-3750
dc.identifier.issue1en_US
dc.identifier.pmid15614192en_US
dc.identifier.scopus2-s2.0-12244272159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageCR29en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22050
dc.identifier.volume11en_US
dc.identifier.wosWOS:000226746500011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaparoscopic Ovarian Drillingen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectHomocysteineen_US
dc.subjectAnovulationen_US
dc.subjectOvulation Inductionen_US
dc.subjectClomipheneen_US
dc.subjectGonadotropinen_US
dc.subjectPlasma Homocysteineen_US
dc.subjectAnovulatory Infertilityen_US
dc.subjectLuteinizing-Hormoneen_US
dc.subjectOvulation Inductionen_US
dc.subjectAdhesion Formationen_US
dc.subjectEndocrine Changesen_US
dc.subjectEarly-Pregnancyen_US
dc.subjectElectrocauteryen_US
dc.subjectDiseaseen_US
dc.subjectMetforminen_US
dc.titleHormone profiles and clinical outcome after laparoscopic ovarian drilling in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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