Prognostic importance of the albumin to globulin ratio in metastatic gastric cancer patients

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dc.authoridDemirci, Nebi Serkan/0000-0001-5943-889X
dc.authoridKöstek, Osman/0000-0002-1901-5603
dc.authorwosidDemirci, Nebi Serkan/V-6186-2017
dc.authorwosidZengin, Nurullah/KBQ-0049-2024
dc.authorwosidKöstek, Osman/AAA-3604-2019
dc.contributor.authorBozkaya, Yakup
dc.contributor.authorErdem, Gokmen Umut
dc.contributor.authorDemirci, Nebi Serkan
dc.contributor.authorYazic, Ozan
dc.contributor.authorOzdemir, Nuriye Yildirim
dc.contributor.authorKostek, Osman
dc.contributor.authorZengin, Nurullah
dc.date.accessioned2024-06-12T11:08:25Z
dc.date.available2024-06-12T11:08:25Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: The aim of this study was to evaluate the prognostic importance of the albumin to globulin ratio (AGR) in terms of overall survival (OS) and progression free survival (PFS) in metastatic gastric cancer patients. Methods: The patients diagnosed with metastatic gastric cancer between 2009 and April 2016 at the hospital have been studied retrospectively. The clinicopathological characteristics, laboratory, and treatment parameters have been assessed. AGR value has been calculated using the following formula (AGR = serum albumin/total protein - serum albumin). Results: In total, 251 patients were included in the study population. The median value of AGR was 1.206 (range = 0.460-3.130), and the cut-off value was set as 1.20. Based on the cut-off value, 126 patients were categorized in the low AGR group, while the remaining 125 patients were categorized in the high AGR group. ECOG (Eastern Cooperative Oncology Group) performance scores, CEA levels, CA19-9 levels, hemoglobin levels, lactate dehydrogenase levels, and liver metastasis ratios varied significantly between the low and high AGR groups (p < .05). The Kaplan-Meier curve has shown that, compared to the low AGR group, the high AGR group has better OS (12.2 vs 9.3 months, p = .002) and better PFS (8.0 vs 5.7 months, p < .001) rates. The univariate and multivariate analyses also proved that low AGR is an independent bad risk factor in metastatic gastric cancer patients, both in terms of OS (p = .019, Hazard Ratio (HR) = 1.380, 95% Confidence Interval (CI) = 1.055-1.805) and PFS (p = .002, HR = 1.514, 95% CI = 1.164-1.968). Conclusion: In metastatic gastric cancer patients, AGR is an independent prognostic factor for OS and PFS. Thus, in this patient group, the low cost albumin and globulin which can be measured with routine clinical practice may be used as an appropriate prognostic tool.en_US
dc.identifier.doi10.1080/03007995.2018.1479683
dc.identifier.endpage282en_US
dc.identifier.issn0300-7995
dc.identifier.issn1473-4877
dc.identifier.issue2en_US
dc.identifier.pmid29785861en_US
dc.identifier.scopus2-s2.0-85048823142en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1080/03007995.2018.1479683
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22426
dc.identifier.volume35en_US
dc.identifier.wosWOS:000454918900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCurrent Medical Research And Opinionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetastatic Gastric Canceren_US
dc.subjectAlbuminen_US
dc.subjectGlobulinen_US
dc.subjectAlbumin To Globulin Ratio: Prognosticen_US
dc.subjectSerum-Albuminen_US
dc.subjectPretreatment Albuminen_US
dc.subjectBreast-Canceren_US
dc.subjectFluorouracilen_US
dc.subjectStatisticsen_US
dc.subjectDocetaxelen_US
dc.subjectMortalityen_US
dc.subjectCisplatinen_US
dc.subjectSurvivalen_US
dc.subjectOutcomesen_US
dc.titlePrognostic importance of the albumin to globulin ratio in metastatic gastric cancer patientsen_US
dc.typeArticleen_US

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