THYROID DYSFUNCTIONS DUE TO LITHIUM TREATMENT IN BIPOLAR DISORDER: CHANGES IN OXIDATIVE STRESS, TRACE ELEMENTS, AND HEMORHEOLOGICAL PARAMETERS

Basit Öğe Kaydı
dc.authoridKızıler, Ali Rıza/0000-0003-0375-1881
dc.authoridAtagun, Murat Ilhan/0000-0002-8514-0576
dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authoridCinemre, Fatma Behice/0000-0002-1972-1575
dc.authoridBAHTİYAR, NURTEN/0000-0003-2420-8415
dc.authorwosidKızıler, Ali Rıza/ABA-6911-2020
dc.authorwosidAtagun, Murat Ilhan/ABA-6588-2021
dc.authorwosidAydemir, Birsen/HKO-5522-2023
dc.authorwosidCinemre, Fatma Behice/JHS-8430-2023
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.authorwosidBAHTİYAR, NURTEN/IZP-9481-2023
dc.contributor.authorBahtiyar, Nurten
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorKiziler, Ali Riza
dc.contributor.authorAtagun, Murat Ilhan
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorAydemir, Birsen
dc.date.accessioned2024-06-12T10:54:43Z
dc.date.available2024-06-12T10:54:43Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLithium is one of the most widely used medications for the treatment of bipolar disorder (BD). It also has some side effects on thyroid functions. We aimed to investigate the role of oxidative stress, trace elements, and hemorheological parameters on the pathophysiology of thyroid dysfunctions developed by lithium treatment in patients with BD. Patients with BD were divided into three groups: patients that non-lithium-treated, lithium-treated patients for 4-6 weeks, and lithium-treated patients for 40-68 weeks. Blood samples for analysis were taken before and after the treatment period. After analysis, patients were divided into six groups: non-treatment BD group (Group 1); short-term lithium-treatment group that did not develop thyroid dysfunctions (Group 2); short-term lithium-treatment group that developed hyperthyroidism (Group 3); long-term lithium treatment group that developed hypothyroidism (Group 4), long-term lithium-treatment group that developed hyperthyroidism (Group 5), and long-term lithium-treatment group that did not develop thyroid dysfunctions (Group 6). Plasma and whole blood viscosity levels were significantly increased in Groups 4 and 6 compared to Groups 1, 2, and 3. Hemoglobin levels were lower in Group 4 than in Groups 1, 2, and 5. Fibrinogen values were higher in Groups 4 and 5 than Group 1. Plasma and erythrocyte malondialdehyde levels were higher in Group 4 than In Groups 1, 2, 3, and 5. Also, they were increased in Group 6 in comparison with Groups 2 and 3. Erythrocyte glutathione levels were lower in Groups 4 and 6 than Groups 1, 2, 3 and 5. Plasma protein carbonyls levels were higher in Group 4 than in Group 1, or in Group 5 than in Groups 1, 2, and 3, as well as in Group 6 than Groups 1, and 2. Serum zinc levels were higher in Groups 2, 3 and 6 than in Group1. Serum copper levels increased in Groups 2, 4 and 6 in comparison with Group1. The results of this study indicate that oxidative stress increased with treatment time in lithium-induced thyroid dysfunctions. Also, whole blood viscosity, plasma viscosity, fibrinogen, zinc, and copper levels were affected by lithium treatment and treatment duration induced thyroid dysfunctions.en_US
dc.identifier.doi10.5601/jelem.2020.25.1.1934
dc.identifier.endpage878en_US
dc.identifier.issn1644-2296
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85092677851en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage863en_US
dc.identifier.urihttps://doi.org/10.5601/jelem.2020.25.1.1934
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19157
dc.identifier.volume25en_US
dc.identifier.wosWOS:000538157700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolish Society Magnesium Researchen_US
dc.relation.ispartofJournal Of Elementologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectLithium Treatmenten_US
dc.subjectThyroid Dysfunctionen_US
dc.subjectOxidative Stressen_US
dc.subjectTrace Elementsen_US
dc.subjectHemorheologyen_US
dc.subjectRed-Blood-Cellsen_US
dc.subjectAntioxidative Enzymesen_US
dc.subjectViscosityen_US
dc.subjectRheologyen_US
dc.subjectTherapyen_US
dc.subjectDiseaseen_US
dc.subjectLipidsen_US
dc.subjectDamageen_US
dc.subjectZincen_US
dc.titleTHYROID DYSFUNCTIONS DUE TO LITHIUM TREATMENT IN BIPOLAR DISORDER: CHANGES IN OXIDATIVE STRESS, TRACE ELEMENTS, AND HEMORHEOLOGICAL PARAMETERSen_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu