Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?

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dc.authoridGÜRGÜL, Serkan/0000-0002-1450-490X
dc.authoriddemirel, can/0000-0001-9334-9866
dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidkilciksiz, Sevil/Y-7790-2018
dc.authorwosidTamer, Lulufer/AAG-5796-2021
dc.authorwosidGÜRGÜL, Serkan/AAC-2995-2020
dc.authorwosiddemirel, can/AAG-8067-2020
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorDemirel, Can
dc.contributor.authorKilciksiz, Sevil Cagiran
dc.contributor.authorGurgul, Serkan
dc.contributor.authorErdal, Nurten
dc.contributor.authorYigit, Seyran
dc.contributor.authorTamer, Lulufer
dc.contributor.authorAyaz, Lokman
dc.date.accessioned2024-06-12T10:50:21Z
dc.date.available2024-06-12T10:50:21Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe lung is relatively sensitive to irradiation. It is shown that acetylsalicylic acid (ASA) might reduce oxidative injury and that it has a place in protection from cancer. The aim of this study is to evaluate the potential radioprotective effects of ASA. Whole-body irradiation (6 Gy, single dose) was applied to the rats. Glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation + ASA (R + ASA; received irradiation and 25 mg/kg of ASA intraperitoneally (i.p.)), and Radiation + Amifostine (R + WR-2721; received irradiation and 200 mg/kg of WR-2721 i.p.) groups were used. The MPO levels decreased statistically significantly in the group administered ASA. Histopathologically, a radioprotective effect of ASA was more evident in the R + ASA group. ASA is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies.en_US
dc.identifier.doi10.1007/s10753-015-0234-x
dc.identifier.endpage165en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.pmid26276129en_US
dc.identifier.scopus2-s2.0-84958045520en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0234-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17974
dc.identifier.volume39en_US
dc.identifier.wosWOS:000370083500018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylsalicylic Acid (ASA)en_US
dc.subjectIrradiation Injuryen_US
dc.subjectLungen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectWR-2721en_US
dc.subjectNonsteroidal Antiinflammatory Drugsen_US
dc.subject5-Aminosalicylic Aciden_US
dc.subjectN-Acetylcysteineen_US
dc.subjectAspirinen_US
dc.subjectRadioprotectionen_US
dc.subjectMechanismsen_US
dc.subjectReductionen_US
dc.subjectInjuryen_US
dc.subjectColonen_US
dc.subjectRisken_US
dc.titleInhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?en_US
dc.typeArticleen_US

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