Decreased nocturnal synthesis of melatonin in patients with coronary artery disease

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.contributor.authorYaprak, M
dc.contributor.authorAltun, A
dc.contributor.authorVardar, A
dc.contributor.authorAktoz, M
dc.contributor.authorCiftci, S
dc.contributor.authorOzbay, G
dc.date.accessioned2024-06-12T11:08:14Z
dc.date.available2024-06-12T11:08:14Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn human beings, cardiovascular activity has a distinct circadian variation: Heart rate, blood pressure, and vascular tone decrease at night. Nocturnal cardiovascular blunting is at least partially linked to the autonomic activity and increased risk of cardiac and cerebral events. To assess whether decreased nocturnal melatonin synthesis and secretion in coronary artery disease (CAD), we investigated nocturnal secretion pattern of melatonin in patients with CAD and healthy subjects. The present study performed in 16 patients with angiographically documented CAD (aged 46-71 years) and in nine healthy controls (aged 36-66 years). Blood samples were collected every 2 h between 22:00 and 08:00 h. Melatonin levels were measured with a commercially available radioimmunoassay kit. We found large interindividual variation in the pattern of melatonin secretion in both groups. Patients with CAD secreted less nocturnal melatonin at 02:00, 04:00 and 08:00 h than control subjects (P=0.014, P=0.04 and P=0.025, respectively). Peak and A melatonin (peak-lowest melatonin) were found lower in patients with CAD (48.6 [19.1-75.4] vs. 131.4 [67.8-137.2] pg/ml, P=0.006 and 43 [10.5-68.5] vs. 107.6 [55.7-113.1] pg/ml, P=0.002, respectively). Peak time of melatonin secretion was observed earlier in patients with CAD (02:00 h [23:00-02:00 h] vs. 03:45 h [02:00-05:00 h], P=0.04). Our study provides useful and preliminary information about decreased nocturnal melatonin synthesis and release in patients with CAD might help physicians in managing these patients. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0167-5273(02)00461-8
dc.identifier.endpage107en_US
dc.identifier.issn0167-5273
dc.identifier.issue1en_US
dc.identifier.pmid12727015en_US
dc.identifier.scopus2-s2.0-0242548489en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1016/S0167-5273(02)00461-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22360
dc.identifier.volume89en_US
dc.identifier.wosWOS:000183165700016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectSympathetic Activationen_US
dc.subjectHeart-Diseaseen_US
dc.subjectCircadian Variationen_US
dc.subjectBlood-Pressureen_US
dc.subjectSecretionen_US
dc.subjectBlockersen_US
dc.subjectEventsen_US
dc.subjectWomenen_US
dc.subjectMenen_US
dc.titleDecreased nocturnal synthesis of melatonin in patients with coronary artery diseaseen_US
dc.typeLetteren_US

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