Comparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102
dc.authorid | Bilici, Ahmet/0000-0002-3192-456X | |
dc.authorid | Cicin, Irfan/0000-0002-7584-3868 | |
dc.authorid | Gökyer, Ali/0000-0002-1653-6155 | |
dc.authorid | Hacioglu, Bekir/0000-0001-8490-3239; | |
dc.authorwosid | Bilici, Ahmet/E-2062-2018 | |
dc.authorwosid | Cicin, Irfan/AAQ-5575-2020 | |
dc.authorwosid | Erdogan, Bulent/AAA-9781-2021 | |
dc.authorwosid | Gökyer, Ali/AAQ-5700-2020 | |
dc.authorwosid | Hacioglu, Bekir/GZH-1824-2022 | |
dc.authorwosid | Kurt, Nazmi/JFA-8132-2023 | |
dc.authorwosid | Küçükarda, Ahmet/AGF-2120-2022 | |
dc.contributor.author | Hacioglu, Muhammet Bekir | |
dc.contributor.author | Kostek, Osman | |
dc.contributor.author | Kurt, Nazmi | |
dc.contributor.author | Kucukarda, Ahmet | |
dc.contributor.author | Gokyer, Ali | |
dc.contributor.author | Ustabasioglu, Fethi Emre | |
dc.contributor.author | Karatas, Fatih | |
dc.date.accessioned | 2024-06-12T11:08:25Z | |
dc.date.available | 2024-06-12T11:08:25Z | |
dc.date.issued | 2019 | |
dc.department | Trakya Üniversitesi | en_US |
dc.description.abstract | Purpose: To assess whether regorafenib and TAS-102 treatments are associated with a change in Skeletal Muscle Area (SMA) as well as to compare Skeletal Muscle Mass (SMM) loss levels between regorafenib and TAS-102 treatments and prognostic significance in the patients with metastatic colorectal cancer (mCRC). Methods: A total of 36 mCRC patients, who received regorafenib or TAS-102 in the third-line and subsequent settings were assessed in the analysis. SMM changes were assessed with CT scans findings, and they were categorized into two groups as SMM-loss (SMM decrease >= 2%) and SMM-stable (SMM change <2%). Results: The SMM change after regorafenib therapy was significantly worse compared with TAS-102 therapy (p=0.001). The median overall survival (OS) was longer in SMM-stable group than in SMM-loss group (12.8 months; 95%CI:9.8-15.7) vs. 6.4 months; 95%CI:5.2-7.7, respectively;p=0.04). Cox regression analysis showed that SMM loss was independent prognostic indicator for OS (HR, 2.87; 95%CI: 1.07-7.42, p=0.03). Conclusion: Although patients who received regorafenib had more SMM loss than those who received TAS-102, there was no difference in OS between drugs. | en_US |
dc.identifier.endpage | 2204 | en_US |
dc.identifier.issn | 1107-0625 | |
dc.identifier.issn | 2241-6293 | |
dc.identifier.issue | 5 | en_US |
dc.identifier.pmid | 31786894 | en_US |
dc.identifier.scopus | 2-s2.0-85075000516 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 2198 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.14551/22424 | |
dc.identifier.volume | 24 | en_US |
dc.identifier.wos | WOS:000501762000062 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Imprimatur Publications | en_US |
dc.relation.ispartof | Journal Of Buon | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Metastatic Colorectal Cancer | en_US |
dc.subject | Regorafenib | en_US |
dc.subject | TAS-102 | en_US |
dc.subject | Sarcopenia | en_US |
dc.subject | Skeletal Muscle Mass | en_US |
dc.subject | Computed-Tomography | en_US |
dc.subject | Treatment Outcomes | en_US |
dc.subject | Sarcopenia | en_US |
dc.subject | Consensus | en_US |
dc.subject | Cachexia | en_US |
dc.subject | Impact | en_US |
dc.subject | Multicenter | en_US |
dc.subject | Definition | en_US |
dc.subject | Validation | en_US |
dc.subject | Guidelines | en_US |
dc.title | Comparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102 | en_US |
dc.type | Article | en_US |