Synthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazoles

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dc.authoridARISOY, MUSTAFA/0000-0002-8260-3918
dc.authoridtemiz arpaci, ozlem/0000-0001-6221-5347
dc.authorwosidarpaci, ozlem temiz/AAH-1281-2020
dc.authorwosidONURDAG, Fatma KAYNAK/T-2518-2017
dc.authorwosidARISOY, MUSTAFA/AAZ-6067-2021
dc.contributor.authorArisoy, Mustafa
dc.contributor.authorTemiz-Arpaci, Ozlem
dc.contributor.authorKaynak-Onurdag, Fatma
dc.contributor.authorOzgen, Selda
dc.date.accessioned2024-06-12T10:54:24Z
dc.date.available2024-06-12T10:54:24Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractA series of 2-(p-substituted phenyl)-5-(2-{4-[(p-chloro-fluorophenyl)/phenyl] piperazin-1-yl}-lacetamido)-benzoxazoles were synthesized and tested for their antimicrobial activities. The structures of the new derivatives were elucidated by spectral techniques. The minimum inhibitory concentrations (MIC) of the new benzoxazoles, along with those of previously synthesized analogues, were determined against standard bacterial and fungal strains and drug-resistant isolates, and compared with those of several reference drugs. The new benzoxazole derivatives were found to possess a broad spectrum of antimicrobial activity with MIC values of 32 - 1024 mu g/ml. Although the standard drugs were more active against the tested pathogens, the activities of the new benzoxazoles and the reference drugs were largely similar against the drug-resistant isolates.en_US
dc.description.sponsorshipAnkara University Research Fund [12L 3336001]en_US
dc.description.sponsorshipThis work was supported by Ankara University Research Fund (grant no. 12L 3336001). The Central Laboratory of the Faculty of Pharmacy, Ankara University, Ankara, Turkey supported the acquisition of the NMR and mass spectra and elemental analyses in this work.en_US
dc.identifier.doi10.5560/ZNC.2014-0024
dc.identifier.endpage374en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue9-10en_US
dc.identifier.pmid25711037en_US
dc.identifier.scopus2-s2.0-84925338380en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage368en_US
dc.identifier.urihttps://doi.org/10.5560/ZNC.2014-0024
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19037
dc.identifier.volume69en_US
dc.identifier.wosWOS:000348967800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal Of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzoxazoleen_US
dc.subjectPiperazineen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectAnalogsen_US
dc.titleSynthesis and Antimicrobial Evaluation of 2-(p-Substituted Phenyl)-5-[(4-substituted piperazin-1-yl)acetamido]-benzoxazolesen_US
dc.typeArticleen_US

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