Plasma total homocysteine level and its association with carotid intima-media thickness in obesity

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dc.authoridUysal, Ömer/0000-0002-8833-697X
dc.authoridCakir, Bilge/0000-0002-3177-4696
dc.authorwosidUysal, Ömer/AAR-4220-2020
dc.authorwosidCakir, Bilge/ABH-3338-2021
dc.contributor.authorUysal, O
dc.contributor.authorArikan, E
dc.contributor.authorCakir, B
dc.date.accessioned2024-06-12T11:09:29Z
dc.date.available2024-06-12T11:09:29Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Elevated plasma concentrations of total homocysteine (tHcy) and obesity are risk factors for cardiovascular disease. The relationship between hyperhomocysteinemia and obesity has not been totally elucidated. Objective: The first aim of the study was to investigate whether anthropometric measurements and insulin resistance contribute to the variation in homocysteine levels in obese adults. Our second aim was to determine if any relationship exists between the carotid intima-media thickness (IMT) and plasma tHcy levels in obese subjects without traditional cardiovascular risk factors. Material and Methods: Fifty-five obese (15 male, 40 female) and 30 (111 male, 19 female) age- and sex-matched apparently healthy volunteers were included. Exclusion criteria were smoking, hypertension, diabetes, vitamin ingestion, hyperlipidemia, renal failure, liver disease, pregnancy, menopause and secondary obesity such as Cushing's syndrome, hypothyroidism. tHcy, folate, vitamin B-12 levels, fasting insulin, glucose, total cholesterol, triglycerides, HDL, LDL particles, uric acid, creatinine and creatinine clearance were measured. Non-invasive ultrasound measurements of carotid IMT were performed. Results: tHcy levels and carotid IMT were comparable between obese and nonobese subjects. Waist/hip ratio (WHR) was related to tHcy and carotid IMT. Hyperhomocysteinemic subjects (tHcy > 19.2 mu mol/l) had greater WH R than normo-homocysteinemic subjects. Both tHcy levels and carotid IMT were higher in male subjects both in obese and non-obese subjects. No association was observed between insulin resistance and tHcy and carotid IMT. Renal function and abdominal obesity were significant predictors of plasma tHcy levels. Conclusions: We concluded that, in obese subjects who are free from atherosclerosis and impaired renal function, plasma tHcy levels do not differ from healthy subjects. Plasma tHcy concentrations are not related to carotid IMT in obese subjects during the non-atherogenic stage. Although no significant difference was observed between insulin-resistant and insulin-sensitive subjects compared to the plasma tHcy levels, the relationship between tHcy levels and some components of the insulin resistance syndrome may support the opinion that tHcy may be considered a component of the insulin resistance syndrome.en_US
dc.identifier.doi10.1007/BF03345325
dc.identifier.endpage934en_US
dc.identifier.issn0391-4097
dc.identifier.issue10en_US
dc.identifier.pmid16419496en_US
dc.identifier.scopus2-s2.0-31544473746en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage928en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345325
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22830
dc.identifier.volume28en_US
dc.identifier.wosWOS:000234296000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectHomocysteineen_US
dc.subjectCarotid IMTen_US
dc.subjectInsulin Resistanceen_US
dc.subjectCardiovascular Risk-Factorsen_US
dc.subjectCoronary-Heart-Diseaseen_US
dc.subjectLife-Styleen_US
dc.subjectHordaland Homocysteineen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectNonobese Subjectsen_US
dc.subjectVascular-Diseaseen_US
dc.subjectHealthyen_US
dc.subjectDeterminantsen_US
dc.titlePlasma total homocysteine level and its association with carotid intima-media thickness in obesityen_US
dc.typeArticleen_US

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