Role of TIMP-2 in fascia transversalis on development of inguinal hernias

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dc.contributor.authorAbci, I
dc.contributor.authorBilgi, S
dc.contributor.authorAltan, A
dc.date.accessioned2024-06-12T11:01:31Z
dc.date.available2024-06-12T11:01:31Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe exact reason for the development of inguinal hernia has not been completely determined. However, it is known that the fascia transversalis ( FT) is one of the structures preventing development of hernias. In the etiology of the inguinal hernia, disorders in collagen metabolism have been proposed, and the role of metalloproteinases in remodeling the collagen has recently been of great importance. We could not encounter any study where the role of metalloproteinase inhibitors was evaluated in inguinal hernia. We obtained samples of FT from patients with direct and indirect hernia and used an immunohistochemical method to determine tissue inhibitor of metalloproteinase-2 ( TIMP-2) expression. In the study group, samples of FT were taken during the operation from 45 patients, of which 35 were indirect and 10 were direct inguinal hernias. In the control group, samples of FT from various abdominal incisions were also taken from 45 patients with no hernia and operated upon for another pathology. TIMP-2 scores of a direct inguinal hernia were significantly less than those of the control group. However, no difference has been found between the TIMP-2 scores of an indirect inguinal hernia and those of the control group. Decreased TIMP- 2 scores in patients with a direct inguinal hernia, compared with both the indirect inguinal hernia group and the control group, explain the reason for the increase in matrix metalloproteinase-2 ( MMP-2) that has been proposed in some studies. Therefore, it can be expressed that a decreased activity of TIMP- 2 plays a role in inguinal hernia development.en_US
dc.identifier.doi10.1080/08941930590956147
dc.identifier.endpage128en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue3en_US
dc.identifier.pmid16036783en_US
dc.identifier.scopus2-s2.0-22944471792en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.1080/08941930590956147
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20926
dc.identifier.volume18en_US
dc.identifier.wosWOS:000230289500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEtiologyen_US
dc.subjectFascia Transversalisen_US
dc.subjectInguinal Herniaen_US
dc.subjectTIMP-2en_US
dc.subjectAdult Groin Herniasen_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectTissue Inhibitorsen_US
dc.subjectCollagenen_US
dc.subjectExpressionen_US
dc.subjectMmp-2en_US
dc.subjectDiseaseen_US
dc.subjectMenen_US
dc.titleRole of TIMP-2 in fascia transversalis on development of inguinal herniasen_US
dc.typeArticleen_US

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