Soybean oil prevents peritoneal adhesions without impairing colonic anastomotic healing

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dc.authoridcolak, Tahsin/0000-0002-7253-5608
dc.authoridComelekoglu, Ulku/0000-0001-8060-6333
dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidcolak, Tahsin/HJP-2646-2023
dc.authorwosidDag, Ahmet/AAV-5939-2020
dc.authorwosidComelekoglu, Ulku/E-2239-2016
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorDag, Ahmet
dc.contributor.authorColak, Tahsin
dc.contributor.authorKoc, Okay
dc.contributor.authorAyaz, Lokman
dc.contributor.authorComelekoglu, Ulku
dc.contributor.authorSerinsoz-Pfeiffer, Ebru
dc.date.accessioned2024-06-12T10:58:06Z
dc.date.available2024-06-12T10:58:06Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Adhesion formation could potentially result in significant morbidity and mortality. In the present study, we investigated the role of soybean oil in the prevention of peritoneal adhesions and its effect on the anastomotic healing process. Patients and Methods: A total of 40 male Wistar Albino rats were randomly assigned to four groups: group A, adhesion induction method; group B, adhesion induction method with administration of soybean oil; group C, colonic anastomosis method; and group D, colonic anastomosis method with administration of soybean oil. Adhesions were scored on postoperative day 7. Anastomotic healing was assessed by determining anastomotic bursting pressure (ABP), tissue hydroxyproline content and the histopathological examination. The serum malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) levels were determined to evaluate cellular response to injury. Results: The difference in mean values between saline-and soybean oil-treated groups, using both the adhesion method and colonic anastomosis method, were statistically significant (P = 0.0003, P = 0.009). Soybean oil administration resulted in no significant difference in terms of ABP and histopathological scores (P = 0.694 and P = 0.246, respectively). Tissue hydroxyproline content was increased significantly with soybean oil administration (P = 0.001). Mean MDA, NO and MPO levels were significantly decreased in the soybean-administered colonic anastomosis group (P = 0.001, P = 0.001, P = 0.002, and respectively). In the soybean-administered adhesion group, mean MDA, NO and MPO levels were lower than in the control group, but the differences were not significant (P = 0.113, P = 0.958, and P = 0.597, respectively). Conclusion: Soybean oil administration intraperitoneally has been shown to prevent adhesion formation effectively without impairing the colonic anastomotic healing process.en_US
dc.identifier.doi10.1111/1744-1633.12120
dc.identifier.endpage105en_US
dc.identifier.issn1744-1625
dc.identifier.issn1744-1633
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84933544425en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.1111/1744-1633.12120
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19943
dc.identifier.volume19en_US
dc.identifier.wosWOS:000359844100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofSurgical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColonic Anastomotic Healingen_US
dc.subjectIntraperitoneal Adhesionen_US
dc.subjectSoybean Oilen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectSurgeryen_US
dc.subjectMulticenteren_US
dc.subjectExpressionen_US
dc.titleSoybean oil prevents peritoneal adhesions without impairing colonic anastomotic healingen_US
dc.typeArticleen_US

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