Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder

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dc.authoridvardar, mehmet erdal/0000-0002-5836-6174
dc.authoridCaliyurt, Okan/0000-0002-0513-0619
dc.authorwosidvardar, mehmet erdal/ABI-5764-2020
dc.authorwosidCaliyurt, Okan/ABE-7339-2020
dc.contributor.authorTuglu, C
dc.contributor.authorKara, SH
dc.contributor.authorCaliyurt, O
dc.contributor.authorVardar, E
dc.contributor.authorAbay, E
dc.date.accessioned2024-06-12T11:08:01Z
dc.date.available2024-06-12T11:08:01Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRationale. Over the last 15 years, an increasing body of evidence has suggested a causal relationship between depression and the immunological activation and hypersecretion of pro-inflammatory cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha (TNF-alpha). However, little is known about the probable relationship of serum TNF-alpha with major depressive disorder (MDD). Objective. To assess whether serum TNF-alpha levels could be associated with the clinical course of MDD. Subjects and methods. TNF-alpha and C-reactive protein (CRP) serum concentrations, erythrocyte sedimentation rate, and leukocyte count were measured in 26 MDD patients and in 17 controls. The measurements were repeated following 6 weeks of antidepressant treatment with selective serotonin re-uptake inhibitors. Psychopathological improvement and the severity of depression were evaluated with the Hamilton Depression Rating Scale (HAMD) and Beck Depression Inventory (BDI). Results. On admission, serum TNF-alpha and leukocyte count were significantly higher in MDD patients compared to controls (P<0.001 and P=0.005, respectively). With the antidepressant treatment, both HAMD and BDI scores decreased significantly (P<0.001 for both). Comparison of pre- and post-treatment measurements revealed that TNF-alpha, CRP, and leukocyte count decreased to levels comparable with those of the control subjects (P<0.001, P=0.01, and P=0.01, respectively). Conclusions. The results emphasized that some immunological parameters, such as CRP, leukocyte count and TNF-alpha, are significantly involved in the clinical course and treatment response in MDD. TNF-alpha in particular could be considered as a potential state marker in MDD.en_US
dc.identifier.doi10.1007/s00213-003-1566-z
dc.identifier.endpage433en_US
dc.identifier.issn0033-3158
dc.identifier.issn1432-2072
dc.identifier.issue4en_US
dc.identifier.pmid12955291en_US
dc.identifier.scopus2-s2.0-0347604853en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1007/s00213-003-1566-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22278
dc.identifier.volume170en_US
dc.identifier.wosWOS:000186831000012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPsychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor Depressionen_US
dc.subjectTumor Necrosis Factoren_US
dc.subjectTreatment Responseen_US
dc.subjectCytokineen_US
dc.subjectSSRIen_US
dc.subjectInduced Sickness Behavioren_US
dc.subjectTo-Brain Communicationen_US
dc.subjectPlasma-Levelsen_US
dc.subjectInflammatory Responseen_US
dc.subjectInterferon-Gammaen_US
dc.subjectCytokinesen_US
dc.subjectInterleukin-1-Betaen_US
dc.subjectSystemen_US
dc.subjectLipopolysaccharideen_US
dc.subjectAntidepressantsen_US
dc.titleIncreased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorderen_US
dc.typeArticleen_US

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