Comparison of the efficacy of the cardiac hypothermia and normothermia to myocardial damage in coronary artery bypass graft surgery with systemic normothermic cardiopulmonary bypass

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dc.authoridCAKIR, HABIB/0000-0002-9968-5198;
dc.authorwosidCAKIR, HABIB/HNB-7714-2023
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidketenciler, serkan/GRN-8241-2022
dc.contributor.authorCakir, H.
dc.contributor.authorGur, O.
dc.contributor.authorEge, T.
dc.contributor.authorKunduracilar, H.
dc.contributor.authorKetenciler, S.
dc.contributor.authorDuran, E.
dc.date.accessioned2024-06-12T10:58:35Z
dc.date.available2024-06-12T10:58:35Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim. The aim of our research is to investigate the cardiac damage formed by either local cardiac hypothermia or cardiac normothermia technique in patients who undergone isolated coronary artery bypass graft (CABG) surgery. Methods. The total of 40 patients who underwent isolated CABG operation under normothermic cardiopulmonary bypass (CPB) were studied. Patients were randomly divided into two groups as cardiac hypothermia and cardiac normothermia. Myocardial temperature was measured from the interventricular septum before aortic cross-clamp (ACC) (baseline), the ACC 20th minutes (ischemia) and after 20 minutes removal of the ACC (reperfusion). The coronary sinus blood samples were simultaneously obtained from the retrograde cardioplegia cannula while myocardial temperature was being measured. Complement component 3 (C3), complement component 4 (C4), troponin I and tumor necrosis factor-alpha (TNF-alpha) was measured from the coronary sinus blood samples. Results. Myocardial temperature was between 18-28 degrees C (deep hypothermia) during ACC in group 1. Myocardial temperature was over 34 degrees C (normothermia) during ACC in group 2. TNF-alpha values of group 1 for ischemia and reperfusion were higher than group 2, and it was found statistically significant (P<0.05). Conclusion. Myocardial damage was less than in normothermia group according to hypothermia group. The results show that ice-cold blood cardioplegia and local ice treatment of the heart during CPB seems to harm the heart more than warm blood cardioplegia.en_US
dc.identifier.endpage401en_US
dc.identifier.issn0021-9509
dc.identifier.issn1827-191X
dc.identifier.issue3en_US
dc.identifier.pmid23369948en_US
dc.identifier.scopus2-s2.0-84879303260en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20113
dc.identifier.volume54en_US
dc.identifier.wosWOS:000320743200011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofJournal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Bypass Graften_US
dc.subjectHypothermiaen_US
dc.subjectCardiac Diseaseen_US
dc.subjectAtrial-Fibrillationen_US
dc.subjectOxygen-Consumptionen_US
dc.subjectWarm Blooden_US
dc.subjectOff-Pumpen_US
dc.subjectCardioplegiaen_US
dc.subjectHearten_US
dc.titleComparison of the efficacy of the cardiac hypothermia and normothermia to myocardial damage in coronary artery bypass graft surgery with systemic normothermic cardiopulmonary bypassen_US
dc.typeArticleen_US

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