The effects of intravenous and local tranexamic acid on bone healing: An experimental study in the rat tibia fracture model

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dc.authoridBalkanlı, Bahadır/0000-0003-4501-9090
dc.authorwosidBalkanlı, Bahadır/HPG-1121-2023
dc.contributor.authorBalkanli, Bahadir
dc.contributor.authorCopuroglu, Cem
dc.contributor.authorCopuroglu, Elif
dc.date.accessioned2024-06-12T11:16:34Z
dc.date.available2024-06-12T11:16:34Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Tranexamic acid (TXA) is an antifibrinolytic agent. It has long been used to reduce the need for perioperative blood loss in various surgeries. Few studies have investigated the effects of local and intravenous administration of TXA on fracture healing. Thus, we aimed to evaluate if TXA influences hematoma volume and fracture healing in the rat tibia fracture model. Materials and methods: A tibia fracture with intramedullary Kirschner wire fixation was created in all animals. Rats were randomly divided into three groups as local TXA, intravenous TXA, and control. A dose of 50 mg/kg local and intravenous TXA was administered to the study groups. Hematoma volume was measured on the first and third days of the study. The animals were sacrificed on the 14th and 21st days for radiological and histopathological examinations. Results: There was no significant difference between the groups in terms of hematoma volume measured on Day 1 and the mean decrease of hematoma volume from Day 1 to Day 3 (p = 0.158 and p = 0.239, respectively). The total radiological scores of Day 14 and Day 21 were similar in all groups (p > 0.05 for all). There was also no significant difference between the histological staging of the fracture repair on Day 14 and Day 21 for all groups (p > 0.05 for all). Conclusion: Our findings suggest that TXA's local and intravenous application makes no significant difference in fracture healing. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.injury.2020.09.008
dc.identifier.endpage2845en_US
dc.identifier.issn0020-1383
dc.identifier.issn1879-0267
dc.identifier.issue12en_US
dc.identifier.pmid32951917en_US
dc.identifier.scopus2-s2.0-85091213240en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2840en_US
dc.identifier.urihttps://doi.org/10.1016/j.injury.2020.09.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24372
dc.identifier.volume51en_US
dc.identifier.wosWOS:000600228400018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInjury-International Journal Of The Care Of The Injureden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTranexamic Aciden_US
dc.subjectTibial Fracturesen_US
dc.subjectFracture Healingen_US
dc.subjectHematomaen_US
dc.subjectRatsen_US
dc.subjectBlood-Lossen_US
dc.subjectHemorrhageen_US
dc.titleThe effects of intravenous and local tranexamic acid on bone healing: An experimental study in the rat tibia fracture modelen_US
dc.typeArticleen_US

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