A study of the effects of sodium benzoate on the mouse liver
Küçük Resim Yok
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the effects of sodium benzoate, on the mouse liver were investigated histopathologically and biochemically. The solutions of 2.5, 3.0, 4.0 and 5.0% of sodium benzoate were applied to the animals in drinking water. The animals treated with 5.0% sodium benzoate died at 8(th) day. At the end of ten days, weight of the animals decreased significantly (p < 0.01, p < 0.001). Total weight and the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and gluthatione peroxidase (Gpx) in the liver were not changed. Microscopical,examination of the liver showed necrotic and cirrhotic changes in the mice fed with sodium benzoate depending on the dose. These changes were tissue degeneration, picnotic nuclei, glassy and vacuolated cytoplasm, nuclear membrane invagination, loss of mitochondrial cristae, plasmorexis, and increasing of the amount of collagen fibers. The results of the present study indicate that sodium benzoate might cause damage by other mechanisms than the oxidative stress in the mouse liver.
Açıklama
Anahtar Kelimeler
Sodium Benzoate, Superoxide Dismutase, Catalase, Glutathione Peroxidase, Mice, Liver, Histopathology, Butylated Hydroxytoluene, Superoxide-Dismutase, Potassium Sorbate, Rat, Peroxidase, Induction, Catalase, Storage, Blood, Mice
Kaynak
Biologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
57
Sayı
3
